iGMDRD608

Canonical SMILES: COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)CC(CO)O)NC3=C(C=C(C=C3)I)F)F)F

InChI: InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1

InChI Key: RDSACQWTXKSHJT-NSHDSACASA-N

Standard NamePubchem CIDDrug StatusDrug Type
Refametinib44182300AloneSmall Molecule


Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
567B2M1
103ADAR1
3845KRAS8
4851NOTCH11
2033EP3002
1846DUSP41
25937WWTR11
2210FCGR1B1
2064ERBB21
6416MAP2K41
3667IRS11
472ATM1
23152CIC1
10413YAP11
1029CDKN2A2
5834PYGB1
3932LCK1
7157TP531
4088SMAD31
3673ITGA22
6714SRC1
6794STK111
3791KDR2
4086SMAD11
6934TCF7L21
4436MSH21
162979ZNF2961
4904YBX11
4089SMAD43
1956EGFR1
4609MYC1
54206ERRFI11
26278SACS1
3553IL1B3
673BRAF9
7027TFDP11
7301TYRO31
5728PTEN2
1869E2F11
171023ASXL11
596BCL21
1027CDKN1B1
2067ERCC11
2776GNAQ1
100862685ERVK-191
5054SERPINE11
196528ARID21
4893NRAS6
7040TGFB11
4613MYCN1
6426SRSF11
5624PROC1

Gene in drug-gene network: Network Plot

Models in Refametinib

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