SRSF1


Summary: This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serine and arginine rich splicing factor 1MIM:600812Ensembl:ENSG00000136450HGNC:HGNC:10780PA3569617q22

GO terms in SRSF1


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIBAGO:0003723RNA binding
MFIDAGO:0003723RNA binding
MFIPIGO:0003723RNA binding
MFIDAGO:0003729mRNA binding
MFIPIGO:0005515protein binding
MFIEAGO:0043422protein kinase B binding
MFIPIGO:0044547DNA topoisomerase binding
MFIEAGO:0050733RS domain binding
CCHDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIBAGO:0016607nuclear speck
CCIDAGO:0016607nuclear speck
CCIDAGO:0035145exon-exon junction complex
CCIDAGO:0071013catalytic step 2 spliceosome
BPIDAGO:0000380alternative mRNA splicing, via spliceosome
BPIBAGO:0000381regulation of alternative mRNA splicing, via spliceosome
BPIDAGO:0000395mRNA 5'-splice site recognition
BPICGO:0000398mRNA splicing, via spliceosome
BPTASGO:0000398mRNA splicing, via spliceosome
BPIEAGO:0001701in utero embryonic development
BPTASGO:0006376mRNA splice site selection
BPTASGO:0006397mRNA processing
BPTASGO:0006405RNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPTASGO:0031124mRNA 3'-end processing
BPIEAGO:0033120positive regulation of RNA splicing
BPIBAGO:0045292mRNA cis splicing, via spliceosome
BPIEAGO:0048709oligodendrocyte differentiation
BPIEAGO:0060048cardiac muscle contraction
BPIEAGO:0097421liver regeneration

Gene expression in normal tissue: SRSF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRSF1


DatabasePathway IDPathway Des.
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72165mRNA Splicing - Minor Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
wikipathwaysWP411mRNA Processing
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD425ERASTIN1
iGMDRD706BRD-K139994671
iGMDRD160Cis-Platin1
iGMDRD608Refametinib1
iGMDRD358Semagacestat1
iGMDRD421AZD77621
iGMDRD45Thalidomide1
iGMDRD946ML3201
iGMDRD394BX-7951

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRSF1

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