SRSF1

Summary: This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameserine and arginine rich splicing factor 1
OMIM IDMIM:600812
Ensembl IDEnsembl:ENSG00000136450
HGNC IDHGNC:HGNC:10780
PHARMGKB IDPA35696
Map Location17q22

GO terms in SRSF1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IBA GO:0003723 RNA binding
MF IDA GO:0003723 RNA binding
MF IPI GO:0003723 RNA binding
MF IDA GO:0003729 mRNA binding
MF IPI GO:0005515 protein binding
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Gene expression in normal tissue: SRSF1

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 4undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 1

Gene-drug pathway distribution

undefined4TNF signaling pathway1Cell cycle1DNA replication1Ferroptosis1ERK MAPK signaling1

Pathways in SRSF1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
reactome R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
reactome R-HSA-72163 mRNA Splicing - Major Pathway
reactome R-HSA-72165 mRNA Splicing - Minor Pathway
reactome R-HSA-72172 mRNA Splicing
reactome R-HSA-72187 mRNA 3'-end processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD425 ERASTIN 1
iGMDRD706 BRD-K13999467 1
iGMDRD160 Cis-Platin 1
iGMDRD608 Refametinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRSF1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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