Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008].

dual specificity phosphatase 4MIM:602747Ensembl:ENSG00000120875HGNC:HGNC:3070PA275278p12

GO terms in DUSP4

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004725protein tyrosine phosphatase activity
MFTASGO:0004725protein tyrosine phosphatase activity
MFIPIGO:0005515protein binding
MFIBAGO:0008138protein tyrosine/serine/threonine phosphatase activity
MFIDAGO:0008330protein tyrosine/threonine phosphatase activity
MFIDAGO:0016791phosphatase activity
MFIBAGO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity
MFIEAGO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity
MFIDAGO:1990439MAP kinase serine/threonine phosphatase activity
BPIBAGO:0000188inactivation of MAPK activity
BPIDAGO:0000188inactivation of MAPK activity
BPIDAGO:0035335peptidyl-tyrosine dephosphorylation
BPIDAGO:0035970peptidyl-threonine dephosphorylation
BPIMPGO:0070373negative regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: DUSP4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DUSP4

DatabasePathway IDPathway Des.
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP382MAPK Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
biocartadsppathwayregulation of map kinase pathways through dual specificity phosphatases
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-202670ERKs are inactivated
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DUSP4