iGMDRD320

Canonical SMILES: CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO

InChI: InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)

InChI Key: JFVNFXCESCXMBC-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NamePIK-93
CHEMBLCHEMBL1229535
Pubchem CID6852170
DRUGBANK IDDB06836
Drug StatusAlone
Drug TypeSmall Molecule


Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Squamous Cell Carcinoma (LUSC) model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

6reactome: Signal Transduction3reactome: Pre-NOTCH Transcription and Translation3reactome: Cell Cycle3reactome: Signaling by NOTCH3reactome: Pre-NOTCH Expression and Processing3reactome: Generic Transcription Pathway3reactome: RNA Polymerase II Transcription3reactome: Cell Cycle, Mitotic3kegg: HTLV-I infection - Homo sapiens (human)3reactome: Metabolism of proteins

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
9757 KMT2B 2
5159 PDGFRB 1
1846 DUSP4 1
5834 PYGB 1
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in PIK-93

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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