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PYGB

Summary: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameglycogen phosphorylase B OMIM IDMIM:138550 Ensembl IDEnsembl:ENSG00000100994 HGNC IDHGNC:HGNC:9723 PHARMGKB IDPA34066 Map Location20p11.21

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DRUGGABLE GENOME

GO terms in PYGB

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008184	glycogen phosphorylase activity
MF	NAS	GO:0008184	glycogen phosphorylase activity
MF	IBA	GO:0030170	pyridoxal phosphate binding
MF	IEA	GO:0102250	linear malto-oligosaccharide phosphorylase activity
MF	IEA	GO:0102499	SHG alpha-glucan phosphorylase activity

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Gene expression in normal tissue: PYGB

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PYGB

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Database	Pathway ID	Pathway Des.
wikipathways	WP500	Glycogen Metabolism
kegg	hsa00500	Starch and sucrose metabolism - Homo sapiens (human)
kegg	hsa04217	Necroptosis - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04922	Glucagon signaling pathway - Homo sapiens (human)
kegg	hsa04931	Insulin resistance - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD119	Temsirolimus	1
iGMDRD286	Nsc 632839	1
iGMDRD662	JQ-1	1
iGMDRD552	AZD-1775	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PYGB

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.