PYGB
Summary: The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glycogen phosphorylase B | MIM:138550 | Ensembl:ENSG00000100994 | HGNC:HGNC:9723 | PA34066 | 20p11.21 |
Gene Categories:
DRUGGABLE GENOMEGO terms in PYGB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008184 | glycogen phosphorylase activity |
| MF | NAS | GO:0008184 | glycogen phosphorylase activity |
| MF | IBA | GO:0030170 | pyridoxal phosphate binding |
| MF | IEA | GO:0102250 | linear malto-oligosaccharide phosphorylase activity |
| MF | IEA | GO:0102499 | SHG alpha-glucan phosphorylase activity |
| BP | IBA | GO:0005980 | glycogen catabolic process |
| BP | NAS | GO:0005980 | glycogen catabolic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PYGB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PYGB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP500 | Glycogen Metabolism |
| kegg | hsa00500 | Starch and sucrose metabolism - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| humancyc | PWY-5941 | glycogenolysis |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-70221 | Glycogen breakdown (glycogenolysis) |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-8982491 | Glycogen metabolism |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD352 | PD-0325901 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD321 | Daporinad | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD641 | SCH 79797 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD847 | BRD-K26531177 | 1 |
| iGMDRD44 | Temozolomide | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD990 | PL.DI | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD864 | BRD-K99006945 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD867 | BRD1835 | 1 |
| iGMDRD36 | Phloretin | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD831 | BCL.LZH.4 | 1 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD628 | BRD-K55116708 | 1 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD145 | Omacetaxine mepesuccinate | 1 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD320 | PIK-93 | 1 |
| iGMDRD480 | KU0060648 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD734 | AZ3146 | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD528 | rigosertib | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD129 | SB-216763 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PYGB
CLASSFICATION
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