iGMDRD734

Canonical SMILES: CN1CCC(CC1)OC2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(C(=O)N4C)C5CCCC5)OC

InChI: InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27)

InChI Key: YUKWVHPTFRQHMF-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameAZ3146
Pubchem CID56973700
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6

Drug-gene pathway enrichments

2reactome: Signal Transduction1wikipathways: Bone Morphogenic Protein (BMP) Signalling and Regulation1kegg: Transcriptional misregulation in cancer - Homo sapiens (human)1kegg: Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)1wikipathways: Angiogenesis1wikipathways: miR-targeted genes in lymphocytes - TarBase1wikipathways: Neural Crest Differentiation1wikipathways: miR-targeted genes in squamous cell - TarBase1kegg: Hippo signaling pathway - Homo sapiens (human)1wikipathways: Heart Development

Drug-gene GO enrichments

5CC: cytoplasm4BP: BMP signaling pathway4CC: nucleus4CC: cytosol3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding3MF: protein binding2BP: negative regulation of protein kinase activity2BP: positive regulation of transcription by RNA polymerase II2BP: glycogen catabolic process2MF: glycogen phosphorylase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5834 PYGB 1
4086 SMAD1 1
84335 AKT1S1 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

SMAD1SMAD1BRD-K55116708BRD-K55116708BRD-K41597374BRD-K41597374PF-573228PF-573228AKT1S1AKT1S1PD-0325901PD-0325901PYGBPYGBAZ3146AZ3146

Models in AZ3146

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(CHK1_pS345) protein MCLP undefined PANCAN AZ.3146 resistance in vitro
EXP(SMAD1) protein MCLP undefined PANCAN AZ.3146 resistance in vitro
EXP(TRANSGLUTAMINASE) protein MCLP undefined PANCAN AZ.3146 sensitivity in vitro
EXP(GPBB) protein MCLP undefined PANCAN AZ.3146 sensitivity in vitro
EXP(H2AX_pS140) protein MCLP undefined PANCAN AZ.3146 resistance in vitro
EXP(PRAS40) protein MCLP undefined PANCAN AZ.3146 sensitivity in vitro
Showing 1 to 6 of 6 rows

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