AKT1S1
Summary: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameAKT1 substrate 1 OMIM IDMIM:610221 Ensembl IDEnsembl:ENSG00000204673 HGNC IDHGNC:HGNC:28426 PHARMGKB IDPA134943587 Map Location19q13.33 | |||||
GO terms in AKT1S1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | IDA | GO:0032007 | negative regulation of TOR signaling |
| BP | IBA | GO:0038202 | TORC1 signaling |
| BP | ISS | GO:0042981 | regulation of apoptotic process |
Gene expression in normal tissue: AKT1S1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKT1S1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKT1S1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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