AKT1S1
Summary: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AKT1 substrate 1 | MIM:610221 | Ensembl:ENSG00000204673 | HGNC:HGNC:28426 | PA134943587 | 19q13.33 |
GO terms in AKT1S1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | IDA | GO:0032007 | negative regulation of TOR signaling |
| BP | IBA | GO:0038202 | TORC1 signaling |
| BP | ISS | GO:0042981 | regulation of apoptotic process |
| BP | ISS | GO:0043523 | regulation of neuron apoptotic process |
| BP | IDA | GO:0045792 | negative regulation of cell size |
| BP | IEA | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0031931 | TORC1 complex |
| CC | IDA | GO:0031931 | TORC1 complex |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: AKT1S1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AKT1S1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD734 | AZ3146 | 1 |
| iGMDRD711 | BRD-K41597374 | 1 |
| iGMDRD452 | PF-573228 | 1 |
| iGMDRD628 | BRD-K55116708 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AKT1S1
CLASSFICATION
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