iGMDRD456
| Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
| Crizotinib | CHEMBL601719 | 11626600 | DB08865 | Alone | Small Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAzolesBradycardia-Causing AgentsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Moderate)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (moderate)Cytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingKinase InhibitorModerate Risk QTc-Prolonging AgentsP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesProtein Kinase InhibitorsQTc Prolonging AgentsDrug Pathways:
RTK signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 7514 | XPO1 | 1 |
| 101927667 | LINC01535 | 1 |
| 2956 | MSH6 | 1 |
| 3845 | KRAS | 2 |
| 6597 | SMARCA4 | 1 |
| 5079 | PAX5 | 1 |
| 4771 | NF2 | 1 |
| 4170 | MCL1 | 1 |
| 27129 | HSPB7 | 1 |
| 1111 | CHEK1 | 1 |
| 8242 | KDM5C | 1 |
| 55294 | FBXW7 | 2 |
| 4610 | MYCL | 1 |
| 4300 | MLLT3 | 1 |
| 91851 | CHRDL1 | 1 |
| 238 | ALK | 104 |
| 2064 | ERBB2 | 2 |
| 6098 | ROS1 | 13 |
| 2778 | GNAS | 1 |
| 1029 | CDKN2A | 3 |
| 5834 | PYGB | 1 |
| 3932 | LCK | 1 |
| 7157 | TP53 | 2 |
| 2305 | FOXM1 | 1 |
| 6794 | STK11 | 1 |
| 4292 | MLH1 | 2 |
| 7495 | XBP1P1 | 1 |
| 4089 | SMAD4 | 1 |
| 407042 | MIR34C | 1 |
| 8731 | RNMT | 103 |
| 5290 | PIK3CA | 1 |
| 4609 | MYC | 1 |
| 1031 | CDKN2C | 2 |
| 673 | BRAF | 2 |
| 81849 | ST6GALNAC5 | 1 |
| 6392 | SDHD | 1 |
| 5728 | PTEN | 1 |
| 1493 | CTLA4 | 1 |
| 7291 | TWIST1 | 1 |
| 100422889 | MIR3194 | 1 |
| 3815 | KIT | 1 |
| 5925 | RB1 | 1 |
| 4893 | NRAS | 2 |
| 25 | ABL1 | 1 |
| 7403 | KDM6A | 1 |
| 374 | AREG | 2 |
| 595 | CCND1 | 1 |
| 4763 | NF1 | 1 |
| 4613 | MYCN | 1 |
| 94 | ACVRL1 | 1 |
| 57699 | CPNE5 | 1 |
| 1499 | CTNNB1 | 1 |
| 5624 | PROC | 1 |
Gene in drug-gene network: Network Plot
Models in Crizotinib
CLASSFICATION
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