CHRDL1
Summary: This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namechordin like 1 OMIM IDMIM:300350 Ensembl IDEnsembl:ENSG00000101938 HGNC IDHGNC:HGNC:29861 PHARMGKB IDPA134933380 Map LocationXq23 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in CHRDL1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| BP | IEA | GO:0001503 | ossification |
| BP | IMP | GO:0001654 | eye development |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: CHRDL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRDL1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | bmppathway | BMP receptor signaling |
| humancyc | PWY66-11 | BMP Signalling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-201451 | Signaling by BMP |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD456 | Crizotinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRDL1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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