CHRDL1
Summary: This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chordin like 1 | MIM:300350 | Ensembl:ENSG00000101938 | HGNC:HGNC:29861 | PA134933380 | Xq23 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CHRDL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| BP | IEA | GO:0001503 | ossification |
| BP | IMP | GO:0001654 | eye development |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030509 | BMP signaling pathway |
| BP | IEA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IMP | GO:0048749 | compound eye development |
Gene expression in normal tissue: CHRDL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRDL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | bmppathway | BMP receptor signaling |
| humancyc | PWY66-11 | BMP Signalling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-201451 | Signaling by BMP |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHRDL1
CLASSFICATION
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