HSPB7
Summary: This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family B (small) member 7 | MIM:610692 | Ensembl:ENSG00000173641 | HGNC:HGNC:5249 | PA29514 | 1p36.13 |
GO terms in HSPB7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0031005 | filamin binding |
| BP | TAS | GO:0006986 | response to unfolded protein |
| BP | IEA | GO:0007507 | heart development |
| BP | TAS | GO:0008016 | regulation of heart contraction |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0015030 | Cajal body |
| CC | IEA | GO:0015629 | actin cytoskeleton |
| CC | IDA | GO:0016235 | aggresome |
Gene expression in normal tissue: HSPB7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPB7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPB7
CLASSFICATION
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