AREG
Summary: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameamphiregulin OMIM IDMIM:104640 Ensembl IDEnsembl:ENSG00000109321 HGNC IDHGNC:HGNC:651 PHARMGKB IDPA24933 Map Location4q13.3 | |||||
GO terms in AREG
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
Gene expression in normal tissue: AREG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AREG
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP288 | NLR Proteins |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AREG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.