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iGMDRD555

Canonical SMILES: CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F

InChI: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

InChI Key: HJBWBFZLDZWPHF-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
ARN-509	CHEMBL3183409	24872600	DB11901	Alone	Small Molecule

Drug Class:

Androgen Antagonists Antiandrogens Cytochrome P-450 CYP2C19 Inducers Cytochrome P-450 CYP2C19 Inducers (strong)Cytochrome P-450 CYP2C9 Inducers Cytochrome P-450 CYP2C9 Inducers (weak)Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inducers (strong)Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strong)Cytochrome P-450 Enzyme Inducers P-glycoprotein/ABCB1 Inducers

Drug Targets:

AR (P10275)GABRA1 (P14867)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
374	AREG	7

Gene in drug-gene network: Network Plot

Models in ARN-509

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DATATYPES

CLASSFICATION

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