iGMDRD555

Canonical SMILES: CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F

InChI: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

InChI Key: HJBWBFZLDZWPHF-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameARN-509
CHEMBLCHEMBL3183409
Pubchem CID24872600
DRUGBANK IDDB11901
Drug StatusAlone
Drug TypeSmall Molecule


Drug-model tissue-cancer distribution: Bubble Plot

PROSTATtissue: PROSTAT cancer: PROSTATE model num: 0PROSTATEtissue: PROSTATE cancer: Prostate Adenocarcinoma (PRAD) model num: 3PROSTATEtissue: PROSTATE cancer: Prostate Cancer model num: 4

Drug-gene pathway enrichments

1reactome: Metabolism of proteins1reactome: COPII-mediated vesicle transport1reactome: Membrane Trafficking1reactome: ER to Golgi Anterograde Transport1reactome: Asparagine N-linked glycosylation1reactome: Vesicle-mediated transport1reactome: Transport to the Golgi and subsequent modification1reactome: Post-translational protein modification1reactome: Cargo concentration in the ER1kegg: Colorectal cancer - Homo sapiens (human)

Drug-gene GO enrichments

2BP: positive regulation of cell proliferation2BP: epidermal growth factor receptor signaling pathway2CC: extracellular space1BP: mammary gland alveolus development1BP: epithelial cell proliferation involved in mammary gland duct elongation1BP: mammary gland branching involved in thelarche1BP: dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis1BP: response to glucocorticoid1BP: response to cAMP1CC: Golgi membrane

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
374 AREG 7
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in ARN-509

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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