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ALK

Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
ALK receptor tyrosine kinase	MIM:105590	Ensembl:ENSG00000171094	HGNC:HGNC:427	PA24719	2p23.2-p23.1

Gene Categories:

SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME TYROSINE KINASE

GO terms in ALK

Term Type	Evidence Type	GO Term ID	GO Des.
MF	TAS	GO:0004704	NF-kappaB-inducing kinase activity
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IDA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	TAS	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding
MF	IPI	GO:0042802	identical protein binding
CC	IEA	GO:0005622	intracellular
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0005887	integral component of plasma membrane
CC	TAS	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0032991	protein-containing complex
CC	IBA	GO:0043235	receptor complex
CC	HDA	GO:0070062	extracellular exosome
BP	TAS	GO:0000187	activation of MAPK activity
BP	IBA	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	IBA	GO:0007275	multicellular organism development
BP	TAS	GO:0008283	cell proliferation
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	IDA	GO:0016310	phosphorylation
BP	TAS	GO:0016310	phosphorylation
BP	IEA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IEA	GO:0021766	hippocampus development
BP	IBA	GO:0030154	cell differentiation
BP	IEA	GO:0030534	adult behavior
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IEA	GO:0036269	swimming behavior
BP	IEA	GO:0038061	NIK/NF-kappaB signaling
BP	IEA	GO:0042127	regulation of cell proliferation
BP	TAS	GO:0042981	regulation of apoptotic process
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IDA	GO:0046777	protein autophosphorylation
BP	TAS	GO:0046777	protein autophosphorylation
BP	TAS	GO:0048666	neuron development
BP	TAS	GO:0051092	positive regulation of NF-kappaB transcription factor activity
BP	IEA	GO:0060159	regulation of dopamine receptor signaling pathway
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IEA	GO:0090648	response to environmental enrichment

Gene expression in normal tissue: ALK

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALK

Database	Pathway ID	Pathway Des.
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05223	Non-small cell lung cancer - Homo sapiens (human)
wikipathways	WP2848	Differentiation Pathway
wikipathways	WP4205	MET in type 1 papillary renal cell carcinoma

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD77	Itraconazole	3
iGMDRD705	Nakiterpiosin	2
iGMDRD221	Tamoxifen	3
iGMDRD289	Parthenolide	3
iGMDRD121	GMX1778	2
iGMDRD137	Indisulam	2
iGMDRD158	NSC141540	2
iGMDRD672	Alectinib	18
iGMDRD275	17-DMAG	3
iGMDRD511	CHEMBL399379	2
iGMDRD768	Lorlatinib	5
iGMDRD532	Olaparib	1
iGMDRD739	Ceritinib	36
iGMDRD524	ISX-9	2
iGMDRD356	PNU-74654	2
iGMDRD23	Gossypol	3
iGMDRD64	Parbendazole	2
iGMDRD188	Piperlongumine	2
iGMDRD52	Rotenone	2
iGMDRD468	AZ628	1
iGMDRD284	Palbociclib	1
iGMDRD466	Chaetocin	2
iGMDRD679	Bistramide A	6
iGMDRD152	179324-69-7	1
iGMDRD483	SCH-529074	3
iGMDRD546	BMS-754807	2
iGMDRD427	ABT737	1
iGMDRD93	2,4-Pyrimidinediamine	2
iGMDRD82	Quiflapon	2
iGMDRD958	novel ALK inhibitor	2
iGMDRD872	BRD7137	2
iGMDRD267	Oligomycin A	2
iGMDRD754	Brigatinib	8
iGMDRD434	BMS-536924	1
iGMDRD85	Ursolic acid	6
iGMDRD345	Compound 10b [PMID: 11504634]	1
iGMDRD299	ICL 670	2
iGMDRD125	BIRB-796	1
iGMDRD456	Crizotinib	104
iGMDRD512	nutlin 3	2
iGMDRD410	Ko-143	1
iGMDRD382	CEP-701	1
iGMDRD451	Serdemetan	2
iGMDRD398	Sepantronium	2
iGMDRD562	Navitoclax	3
iGMDRD724	AZD3463	1
iGMDRD887	Compound 23 citrate	2
iGMDRD100	Zebularine	5
iGMDRD309	17AAG	2
iGMDRD255	SB225002	3
iGMDRD700	AUY922	1
iGMDRD491	TAE-684	10
iGMDRD138	PX 12	4
iGMDRD280	CYTOCHALASIN B	2
iGMDRD378	ZM-447439	1
iGMDRD163	all trans Retinoic Acid	1
iGMDRD498	GW441756X	1
iGMDRD446	LY 2183240	2
iGMDRD129	SB-216763	1
iGMDRD1008	SR-II-138A	2
iGMDRD579	PF750	2
iGMDRD599	Salermide	2
iGMDRD313	Axitinib	1
iGMDRD112	Methotrexate	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALK

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.