iGMDRD768

Canonical SMILES: CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C

InChI: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChI Key: IIXWYSCJSQVBQM-LLVKDONJSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameLorlatinib
CHEMBLCHEMBL3286830
Pubchem CID71731800
DRUGBANK IDDB12130
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Adenoid Cystic Carcinoma of the Lung (LUACC) model num: 1LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 4BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Neuroblastoma (NBL) model num: 3

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
238 ALK 5
6098 ROS1 2
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in Lorlatinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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