ROS1
Summary: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ROS proto-oncogene 1, receptor tyrosine kinase | MIM:165020 | Ensembl:ENSG00000047936 | HGNC:HGNC:10261 | PA34633 | 6q22.1 |
GO terms in ROS1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IEA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IDA | GO:0001558 | regulation of cell growth |
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | ISS | GO:0002066 | columnar/cuboidal epithelial cell development |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0010966 | regulation of phosphate transport |
| BP | IEA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030154 | cell differentiation |
| BP | IDA | GO:0032006 | regulation of TOR signaling |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
Gene expression in normal tissue: ROS1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ROS1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3630 | NAD metabolism, sirtuins and aging |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD724 | AZD3463 | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD602 | Foretinib | 5 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD920 | HSP90 inhibitor | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD441 | TW 37 | 6 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 8 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD571 | Cabozantinib | 5 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 4 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD754 | Brigatinib | 1 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD739 | Ceritinib | 1 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD768 | Lorlatinib | 2 |
| iGMDRD456 | Crizotinib | 13 |
| iGMDRD532 | Olaparib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ROS1
CLASSFICATION
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