ROS1


Summary: This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in ROS1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF IDA GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IEA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IBA GO:0004888 transmembrane signaling receptor activity
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Gene expression in normal tissue: ROS1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41RTK signaling3Biosynthesis of secondary metabolites2Stilbenoid, diarylheptanoid and gingerol biosynthesis1Genome integrity1Drug metabolism - cytochrome P4501Chromatin histone acetylation1Metabolism1Other, kinases1ERK MAPK signaling1

Pathways in ROS1


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Database
Pathway ID
Pathway Des.
wikipathways WP2431 Spinal Cord Injury
wikipathways WP3630 NAD metabolism, sirtuins and aging
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD724 AZD3463 1
iGMDRD399 Selumetinib 2
iGMDRD188 Piperlongumine 1
iGMDRD100 Zebularine 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ROS1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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