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iGMDRD754

Canonical SMILES: CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC

InChI: InChI=1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34)

InChI Key: AILRADAXUVEEIR-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Brigatinib	CHEMBL3545311	68165300	DB12267	Alone	Small Molecule

Drug Class:

BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Kinase Inhibitor

Drug Targets:

ALK (Q9UM73)EGFR (P00533)ABL1 (P00519)IGF1R (P08069)FLT3 (P36888)INSR (P06213)MET (P08581)ERBB4 (Q15303)ERBB2 (P04626)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
238	ALK	8
6098	ROS1	1

Gene in drug-gene network: Network Plot

Models in Brigatinib

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.