iGMDRD221
| Standard Name | CHEMBL | Pubchem CID | KEGG Drug ID | DRUGBANK ID | Drug Status | Drug targets (TTD) | Drug Type |
|---|---|---|---|---|---|---|---|
| Tamoxifen | CHEMBL786 CHEMBL83 | 2733530 | D08559 | DB00675 | Alone | DAP000108 | Small Molecule |
Drug Class:
Anti-EstrogensAntineoplastic AgentsAntineoplastic Agents, HormonalAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesBenzene DerivativesBenzylidene CompoundsBone Density Conservation AgentsCardiotoxic antineoplastic agentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (moderate)Cytochrome P-450 CYP2D6 SubstratesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 CYP3A5 SubstratesCytochrome P-450 CYP3A7 SubstratesCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEndocrine TherapyEstrogen Agonist/AntagonistEstrogen AntagonistsEstrogen Receptor ModulatorsHormone AntagonistsHormone Antagonists and Related AgentsHormones, Hormone Substitutes, and Hormone AntagonistsHydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicP-glycoprotein/ABCB1 InducersP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPotential QTc-Prolonging AgentsQTc Prolonging AgentsSelective Estrogen Receptor ModulatorsStilbenesDrug Targets:
ERESR1 (P03372)ESR2 (Q92731)EBP (Q15125)PRKCA (P17252)AR (P10275)KCNH2 (Q12809)NR1I2 (O75469)ESRRG (P62508)SHBG (P04278)Drug Pathways:
Estrogen signaling pathwayPathways in cancerHormone-relatedDrug metabolism - cytochrome P450Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 331 | XIAP | 5 |
| 8019 | BRD3 | 3 |
| 6774 | STAT3 | 3 |
| 7750 | ZMYM2 | 2 |
| 2986 | GUCY2F | 2 |
| 51773 | RSF1 | 1 |
| 2200 | FBN1 | 2 |
| 399 | RHOH | 3 |
| 1520 | CTSS | 6 |
| 4750 | NEK1 | 3 |
| 8289 | ARID1A | 4 |
| 51231 | VRK3 | 3 |
| 25778 | DSTYK | 5 |
| 79092 | CARD14 | 5 |
| 5241 | PGR | 2 |
| 353345 | GPR141 | 3 |
| 3069 | HDLBP | 3 |
| 79820 | CATSPERB | 2 |
| 5079 | PAX5 | 4 |
| 4771 | NF2 | 1 |
| 23235 | SIK2 | 5 |
| 10142 | AKAP9 | 3 |
| 7253 | TSHR | 4 |
| 3195 | TLX1 | 3 |
| 3841 | KPNA5 | 3 |
| 943 | TNFRSF8 | 3 |
| 80122 | MAP3K19 | 5 |
| 114783 | LMTK3 | 2 |
| 1813 | DRD2 | 3 |
| 1387 | CREBBP | 6 |
| 5788 | PTPRC | 6 |
| 5579 | PRKCB | 2 |
| 31 | ACACA | 6 |
| 9699 | RIMS2 | 2 |
| 85021 | REPS1 | 2 |
| 5159 | PDGFRB | 1 |
| 10215 | OLIG2 | 1 |
| 2033 | EP300 | 1 |
| 8784 | TNFRSF18 | 2 |
| 10746 | MAP3K2 | 6 |
| 4595 | MUTYH | 3 |
| 57670 | KIAA1549 | 3 |
| 4610 | MYCL | 2 |
| 816 | CAMK2B | 2 |
| 342667 | STAC2 | 3 |
| 5607 | MAP2K5 | 3 |
| 11073 | TOPBP1 | 6 |
| 2051 | EPHB6 | 3 |
| 222484 | LNX2 | 1 |
| 329 | BIRC2 | 5 |
| 26353 | HSPB8 | 3 |
| 22806 | IKZF3 | 3 |
| 8313 | AXIN2 | 3 |
| 6733 | SRPK2 | 3 |
| 2042 | EPHA3 | 4 |
| 114548 | NLRP3 | 1 |
| 5984 | RFC4 | 3 |
| 51804 | SIX4 | 3 |
| 269 | AMHR2 | 1 |
| 7037 | TFRC | 3 |
| 238 | ALK | 3 |
| 375449 | MAST4 | 3 |
| 10551 | AGR2 | 1 |
| 2064 | ERBB2 | 1 |
| 79971 | WLS | 2 |
| 23191 | CYFIP1 | 3 |
| 1452 | CSNK1A1 | 2 |
| 65987 | KCTD14 | 3 |
| 64170 | CARD9 | 3 |
| 6709 | SPTAN1 | 3 |
| 8215 | DVL1P1 | 3 |
| 158056 | MAMDC4 | 2 |
| 10087 | COL4A3BP | 3 |
| 5568 | PRKACG | 3 |
| 7507 | XPA | 3 |
| 6098 | ROS1 | 2 |
| 9472 | AKAP6 | 2 |
| 157285 | PRAG1 | 3 |
| 638 | BIK | 3 |
| 3685 | ITGAV | 2 |
| 8148 | TAF15 | 2 |
| 53942 | CNTN5 | 5 |
| 3397 | ID1 | 1 |
| 5924 | RASGRF2 | 1 |
| 4058 | LTK | 3 |
| 1123 | CHN1 | 2 |
| 1496 | CTNNA2 | 6 |
| 7533 | YWHAH | 3 |
| 5450 | POU2AF1 | 8 |
| 8798 | DYRK4 | 3 |
| 959 | CD40LG | 3 |
| 57523 | NYNRIN | 3 |
| 83694 | RPS6KL1 | 3 |
| 27347 | STK39 | 2 |
| 2099 | ESR1 | 15 |
| 26281 | FGF20 | 3 |
| 3000 | GUCY2D | 3 |
| 130399 | ACVR1C | 3 |
| 84075 | FSCB | 3 |
| 9967 | THRAP3 | 2 |
| 4869 | NPM1 | 2 |
| 8874 | ARHGEF7 | 2 |
| 10516 | FBLN5 | 2 |
| 7038 | TG | 1 |
| 65125 | WNK1 | 1 |
| 50945 | TBX22 | 3 |
| 676 | BRDT | 6 |
| 57578 | UNC79 | 2 |
| 4437 | MSH3 | 5 |
| 4089 | SMAD4 | 1 |
| 54658 | UGT1A1 | 1 |
| 1616 | DAXX | 3 |
| 23373 | CRTC1 | 3 |
| 546 | ATRX | 2 |
| 5606 | MAP2K3 | 3 |
| 340533 | NEXMIF | 3 |
| 8731 | RNMT | 2 |
| 5290 | PIK3CA | 2 |
| 8202 | NCOA3 | 1 |
| 4293 | MAP3K9 | 2 |
| 6391 | SDHC | 3 |
| 64333 | ARHGAP9 | 6 |
| 90956 | ADCK2 | 3 |
| 4684 | NCAM1 | 4 |
| 29951 | PDZRN4 | 2 |
| 5663 | PSEN1 | 4 |
| 3553 | IL1B | 1 |
| 23604 | DAPK2 | 3 |
| 9159 | PCSK7 | 2 |
| 7033 | TFF3 | 1 |
| 57538 | ALPK3 | 3 |
| 5598 | MAPK7 | 2 |
| 65268 | WNK2 | 3 |
| 5979 | RET | 3 |
| 654780 | LOC654780 | 3 |
| 8491 | MAP4K3 | 3 |
| 9509 | ADAMTS2 | 5 |
| 5563 | PRKAA2 | 4 |
| 23742 | NPAP1 | 2 |
| 7030 | TFE3 | 3 |
| 7155 | TOP2B | 2 |
| 667 | DST | 4 |
| 3554 | IL1R1 | 3 |
| 7042 | TGFB2 | 3 |
| 5582 | PRKCG | 7 |
| 55356 | SLC22A15 | 3 |
| 79012 | CAMKV | 3 |
| 2046 | EPHA8 | 1 |
| 4297 | KMT2A | 1 |
| 5291 | PIK3CB | 2 |
| 5562 | PRKAA1 | 6 |
| 53353 | LRP1B | 2 |
| 7094 | TLN1 | 3 |
| 63976 | PRDM16 | 2 |
| 7293 | TNFRSF4 | 5 |
| 6093 | ROCK1 | 3 |
| 2194 | FASN | 3 |
| 5587 | PRKD1 | 2 |
| 4215 | MAP3K3 | 3 |
| 1719 | DHFR | 5 |
| 57007 | ACKR3 | 3 |
| 23139 | MAST2 | 3 |
| 53335 | BCL11A | 2 |
| 3709 | ITPR2 | 1 |
| 57118 | CAMK1D | 3 |
| 84254 | CAMKK1 | 3 |
| 8428 | STK24 | 3 |
| 3516 | RBPJ | 2 |
| 80216 | ALPK1 | 2 |
| 4261 | CIITA | 1 |
| 23250 | ATP11A | 2 |
| 5925 | RB1 | 1 |
| 7124 | TNF | 4 |
| 25 | ABL1 | 2 |
| 3691 | ITGB4 | 3 |
| 7403 | KDM6A | 1 |
| 5586 | PKN2 | 3 |
| 30849 | PIK3R4 | 2 |
| 79728 | PALB2 | 3 |
| 595 | CCND1 | 2 |
| 4763 | NF1 | 2 |
| 9625 | AATK | 2 |
| 63893 | UBE2O | 2 |
| 5288 | PIK3C2G | 2 |
| 2044 | EPHA5 | 1 |
| 5287 | PIK3C2B | 1 |
| 6868 | ADAM17 | 3 |
| 2892 | GRIA3 | 1 |
| 2886 | GRB7 | 3 |
| 5590 | PRKCZ | 2 |
Gene in drug-gene network: Network Plot
Models in Tamoxifen
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.