RFC4
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:102577 Ensembl IDEnsembl:ENSG00000163918 HGNC IDHGNC:HGNC:9972 PHARMGKB IDPA34341 Map Location3q27.3 | |||||
Gene Categories:
DNA REPAIRGO terms in RFC4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003689 | DNA clamp loader activity |
| MF | IDA | GO:0003689 | DNA clamp loader activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IDA | GO:0043142 | single-stranded DNA-dependent ATPase activity |
Gene expression in normal tissue: RFC4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RFC4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RFC4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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