RFC4
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| replication factor C subunit 4 | MIM:102577 | Ensembl:ENSG00000163918 | HGNC:HGNC:9972 | PA34341 | 3q27.3 |
Gene Categories:
DNA REPAIRGO terms in RFC4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003689 | DNA clamp loader activity |
| MF | IDA | GO:0003689 | DNA clamp loader activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019899 | enzyme binding |
| MF | IDA | GO:0043142 | single-stranded DNA-dependent ATPase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005663 | DNA replication factor C complex |
| CC | IDA | GO:0005663 | DNA replication factor C complex |
| CC | IDA | GO:0031390 | Ctf18 RFC-like complex |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006261 | DNA-dependent DNA replication |
| BP | TAS | GO:0006271 | DNA strand elongation involved in DNA replication |
| BP | IBA | GO:0006281 | DNA repair |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | TAS | GO:0042276 | error-prone translesion synthesis |
| BP | TAS | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | TAS | GO:0070987 | error-free translesion synthesis |
| BP | IDA | GO:1900264 | positive regulation of DNA-directed DNA polymerase activity |
Gene expression in normal tissue: RFC4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RFC4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
| pid | atr_pathway | ATR signaling pathway |
| pid | fanconi_pathway | Fanconi anemia pathway |
| reactome | R-HSA-110312 | Translesion synthesis by REV1 |
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex |
| reactome | R-HSA-110320 | Translesion Synthesis by POLH |
| reactome | R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174411 | Polymerase switching on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair |
| reactome | R-HSA-5655862 | Translesion synthesis by POLK |
| reactome | R-HSA-5656121 | Translesion synthesis by POLI |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69091 | Polymerase switching |
| reactome | R-HSA-69109 | Leading Strand Synthesis |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD394 | BX-795 | 6 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD192 | CIL56 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RFC4
CLASSFICATION
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