EPHB6
Summary: This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
NameEPH receptor B6 OMIM IDMIM:602757 Ensembl IDEnsembl:ENSG00000106123 HGNC IDHGNC:HGNC:3396 PHARMGKB IDPA27828 Map Location7q34 |
GO terms in EPHB6
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | TAS | GO:0005576 | extracellular region |
CC | IBA | GO:0005737 | cytoplasm |
CC | TAS | GO:0005829 | cytosol |
CC | TAS | GO:0005886 | plasma membrane |
CC | IBA | GO:0005887 | integral component of plasma membrane |
CC | IEA | GO:0005887 | integral component of plasma membrane |
Gene expression in normal tissue: EPHB6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB6
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-1266738 | Developmental Biology |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-2682334 | EPH-Ephrin signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB6
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |