EPHB6

Summary: This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameEPH receptor B6
OMIM IDMIM:602757
Ensembl IDEnsembl:ENSG00000106123
HGNC IDHGNC:HGNC:3396
PHARMGKB IDPA27828
Map Location7q34

GO terms in EPHB6


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IBA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC TAS GO:0005886 plasma membrane
CC IBA GO:0005887 integral component of plasma membrane
CC IEA GO:0005887 integral component of plasma membrane
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Gene expression in normal tissue: EPHB6

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 43undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 4undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 16BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6

Gene-drug pathway distribution

undefined22Apoptosis regulation2Stilbenoid, diarylheptanoid and gingerol biosynthesis1PI3K/MTOR signaling1Drug metabolism - cytochrome P4501DNA replication1Proteasome1Biosynthesis of secondary metabolites1Th17 cell differentiation1Metabolism1

Pathways in EPHB6


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-2682334 EPH-Ephrin signaling
reactome R-HSA-3928662 EPHB-mediated forward signaling
reactome R-HSA-3928662 EPHB-mediated forward signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 4
iGMDRD888 Compound 44 1
iGMDRD398 Sepantronium 4
iGMDRD562 Navitoclax 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHB6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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