DRD2


Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:126450
PHARMGKB IDPA27478
Map Location11q23.2

GO terms in DRD2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0001659 temperature homeostasis
BP IEA GO:0001666 response to hypoxia
BP IEA GO:0001933 negative regulation of protein phosphorylation
BP ISS GO:0001975 response to amphetamine
BP ISS GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure
BP ISS GO:0002027 regulation of heart rate
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Gene expression in normal tissue: DRD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined12Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Drug metabolism - cytochrome P4501Protein stability and degradation1Apoptosis regulation1

Pathways in DRD2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
reactome R-HSA-375280 Amine ligand-binding receptors
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-390651 Dopamine receptors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD318 PAC-1 9
iGMDRD415 LE-135 3
iGMDRD782 DC-45-A2 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DRD2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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