DRD2
Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:126450 Ensembl IDEnsembl:ENSG00000149295 HGNC IDHGNC:HGNC:3023 PHARMGKB IDPA27478 Map Location11q23.2 |
Gene Categories:
NEUTRAL ZINC METALLOPEPTIDASERNA DIRECTED DNA POLYMERASEDNA REPAIRTRANSPORTERGROWTH FACTORNUCLEAR HORMONE RECEPTORPHOSPHOLIPASEPROTEIN PHOSPHATASETRANSCRIPTION FACTOR COMPLEXION CHANNELKINASEPROTEASEABC TRANSPORTERHORMONE ACTIVITYLIPID KINASEG PROTEIN COUPLED RECEPTORTYROSINE KINASEEXTERNAL SIDE OF PLASMA MEMBRANEPROTEASE INHIBITORSERINE THREONINE KINASEDRUGGABLE GENOMEHISTONE MODIFICATIONCELL SURFACEDRUG METABOLISMTRANSCRIPTION FACTOR BINDINGTUMOR SUPPRESSORDRUG RESISTANCEGO terms in DRD2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0001659 | temperature homeostasis |
BP | IEA | GO:0001666 | response to hypoxia |
BP | IEA | GO:0001933 | negative regulation of protein phosphorylation |
BP | ISS | GO:0001975 | response to amphetamine |
BP | ISS | GO:0001976 | neurological system process involved in regulation of systemic arterial blood pressure |
BP | ISS | GO:0002027 | regulation of heart rate |
Gene expression in normal tissue: DRD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DRD2
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
reactome | R-HSA-375280 | Amine ligand-binding receptors |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-390651 | Dopamine receptors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in DRD2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |