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DRD2

Summary: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
dopamine receptor D2	MIM:126450	Ensembl:ENSG00000149295	HGNC:HGNC:3023	PA27478	11q23.2

Gene Categories:

NEUTRAL ZINC METALLOPEPTIDASE RNA DIRECTED DNA POLYMERASE DNA REPAIR TRANSPORTER GROWTH FACTOR NUCLEAR HORMONE RECEPTOR PHOSPHOLIPASE PROTEIN PHOSPHATASE TRANSCRIPTION FACTOR COMPLEX ION CHANNEL KINASE PROTEASE ABC TRANSPORTER HORMONE ACTIVITY LIPID KINASE G PROTEIN COUPLED RECEPTOR TYROSINE KINASE EXTERNAL SIDE OF PLASMA MEMBRANE PROTEASE INHIBITOR SERINE THREONINE KINASE DRUGGABLE GENOME HISTONE MODIFICATION CELL SURFACE DRUG METABOLISM TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR DRUG RESISTANCE

GO terms in DRD2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0001659	temperature homeostasis
BP	IEA	GO:0001666	response to hypoxia
BP	IEA	GO:0001933	negative regulation of protein phosphorylation
BP	ISS	GO:0001975	response to amphetamine
BP	ISS	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
BP	ISS	GO:0002027	regulation of heart rate
BP	ISS	GO:0002028	regulation of sodium ion transport
BP	IEA	GO:0002031	G-protein coupled receptor internalization
BP	ISS	GO:0002052	positive regulation of neuroblast proliferation
BP	IEA	GO:0002092	positive regulation of receptor internalization
BP	IEA	GO:0006914	autophagy
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	IBA	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
BP	IDA	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
BP	IBA	GO:0007267	cell-cell signaling
BP	ISS	GO:0007270	neuron-neuron synaptic transmission
BP	ISS	GO:0007409	axonogenesis
BP	ISS	GO:0007416	synapse assembly
BP	ISS	GO:0007608	sensory perception of smell
BP	IEA	GO:0007616	long-term memory
BP	IEA	GO:0007625	grooming behavior
BP	ISS	GO:0007626	locomotory behavior
BP	ISS	GO:0007628	adult walking behavior
BP	ISS	GO:0008104	protein localization
BP	ISS	GO:0008285	negative regulation of cell proliferation
BP	ISS	GO:0008306	associative learning
BP	ISS	GO:0008542	visual learning
BP	ISS	GO:0009416	response to light stimulus
BP	IEA	GO:0010039	response to iron ion
BP	IEA	GO:0014854	response to inactivity
BP	IEA	GO:0016055	Wnt signaling pathway
BP	IEA	GO:0021756	striatum development
BP	IEA	GO:0021769	orbitofrontal cortex development
BP	ISS	GO:0021853	cerebral cortex GABAergic interneuron migration
BP	ISS	GO:0021984	adenohypophysis development
BP	ISS	GO:0030336	negative regulation of cell migration
BP	ISS	GO:0030432	peristalsis
BP	IEA	GO:0031223	auditory behavior
BP	IEA	GO:0032147	activation of protein kinase activity
BP	ISS	GO:0032228	regulation of synaptic transmission, GABAergic
BP	IMP	GO:0032467	positive regulation of cytokinesis
BP	ISS	GO:0032922	circadian regulation of gene expression
BP	IEA	GO:0033602	negative regulation of dopamine secretion
BP	IDA	GO:0034776	response to histamine
BP	IEA	GO:0035094	response to nicotine
BP	IEA	GO:0035810	positive regulation of urine volume
BP	IEA	GO:0035815	positive regulation of renal sodium excretion
BP	IEA	GO:0040018	positive regulation of multicellular organism growth
BP	ISS	GO:0042220	response to cocaine
BP	IEA	GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
BP	IC	GO:0042417	dopamine metabolic process
BP	ISS	GO:0042493	response to drug
BP	IEA	GO:0042756	drinking behavior
BP	ISS	GO:0043266	regulation of potassium ion transport
BP	ISS	GO:0043278	response to morphine
BP	IEA	GO:0043473	pigmentation
BP	IEA	GO:0043666	regulation of phosphoprotein phosphatase activity
BP	IEA	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
BP	ISS	GO:0045776	negative regulation of blood pressure
BP	IEA	GO:0045824	negative regulation of innate immune response
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0046676	negative regulation of insulin secretion
BP	ISS	GO:0048148	behavioral response to cocaine
BP	ISS	GO:0048149	behavioral response to ethanol
BP	ISS	GO:0048169	regulation of long-term neuronal synaptic plasticity
BP	IEA	GO:0048678	response to axon injury
BP	ISS	GO:0048755	branching morphogenesis of a nerve
BP	IDA	GO:0050482	arachidonic acid secretion
BP	IDA	GO:0050709	negative regulation of protein secretion
BP	ISS	GO:0051209	release of sequestered calcium ion into cytosol
BP	IC	GO:0051584	regulation of dopamine uptake involved in synaptic transmission
BP	ISS	GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
BP	IEA	GO:0051823	regulation of synapse structural plasticity
BP	ISS	GO:0051898	negative regulation of protein kinase B signaling
BP	NAS	GO:0051898	negative regulation of protein kinase B signaling
BP	ISS	GO:0051967	negative regulation of synaptic transmission, glutamatergic
BP	NAS	GO:0060079	excitatory postsynaptic potential
BP	ISS	GO:0060124	positive regulation of growth hormone secretion
BP	ISS	GO:0060134	prepulse inhibition
BP	IGI	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
BP	ISS	GO:0060160	negative regulation of dopamine receptor signaling pathway
BP	IEA	GO:0060548	negative regulation of cell death
BP	IEA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IBA	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
BP	IEA	GO:0090325	regulation of locomotion involved in locomotory behavior
BP	IDA	GO:1900168	positive regulation of glial cell-derived neurotrophic factor secretion
BP	IEA	GO:1900273	positive regulation of long-term synaptic potentiation
CC	IEA	GO:0001669	acrosomal vesicle
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0014069	postsynaptic density
CC	IEA	GO:0016328	lateral plasma membrane
CC	IEA	GO:0030139	endocytic vesicle
CC	ISS	GO:0030424	axon
CC	ISS	GO:0030425	dendrite
CC	IEA	GO:0036126	sperm flagellum
CC	IEA	GO:0043197	dendritic spine
CC	IEA	GO:0043204	perikaryon
CC	IEA	GO:0043679	axon terminus
CC	IDA	GO:0060170	ciliary membrane
CC	IDA	GO:0097730	non-motile cilium
MF	IDA	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
MF	IBA	GO:0004935	adrenergic receptor activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008144	drug binding
MF	IEA	GO:0035255	ionotropic glutamate receptor binding
MF	IPI	GO:0042802	identical protein binding
MF	IEA	GO:0042803	protein homodimerization activity
MF	IEA	GO:0046982	protein heterodimerization activity

Gene expression in normal tissue: DRD2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DRD2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-373076	Class A/1 (Rhodopsin-like receptors)
reactome	R-HSA-375280	Amine ligand-binding receptors
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-390651	Dopamine receptors
reactome	R-HSA-418594	G alpha (i) signalling events
reactome	R-HSA-500792	GPCR ligand binding
biocarta	ck1pathway	regulation of ck1/cdk5 by type 1 glutamate receptors
pharmgkb	PA162355621	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04080	Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegg	hsa04540	Gap junction - Homo sapiens (human)
kegg	hsa04728	Dopaminergic synapse - Homo sapiens (human)
kegg	hsa05012	Parkinson,s disease - Homo sapiens (human)
kegg	hsa05030	Cocaine addiction - Homo sapiens (human)
kegg	hsa05034	Alcoholism - Homo sapiens (human)
wikipathways	WP1602	Nicotine Activity on Dopaminergic Neurons
wikipathways	WP2636	Common Pathways Underlying Drug Addiction
wikipathways	WP4222	Phosphodiesterases in neuronal function
wikipathways	WP455	GPCRs, Class A Rhodopsin-like
wikipathways	WP58	Monoamine GPCRs

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	1
iGMDRD318	PAC-1	9
iGMDRD415	LE-135	3
iGMDRD782	DC-45-A2	3
iGMDRD221	Tamoxifen	3
iGMDRD158	NSC141540	3
iGMDRD202	Curcumin	6
iGMDRD271	Brefeldin A	3
iGMDRD82	Quiflapon	6
iGMDRD427	ABT737	3
iGMDRD584	VER 155008	1
iGMDRD84	Lovastatin acid	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	4
iGMDRD280	CYTOCHALASIN B	6
iGMDRD679	Bistramide A	2
iGMDRD394	BX-795	3
iGMDRD499	PDMP	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DRD2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.