PALB2
Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| partner and localizer of BRCA2 | MIM:610355 | Ensembl:ENSG00000083093 | HGNC:HGNC:26144 | PA162398608 | 16p12.2 |
GO terms in PALB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| BP | IDA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IMP | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IEA | GO:0001756 | somitogenesis |
| BP | IEA | GO:0001833 | inner cell mass cell proliferation |
| BP | IEA | GO:0007498 | mesoderm development |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IEA | GO:0036342 | post-anal tail morphogenesis |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0048568 | embryonic organ development |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: PALB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PALB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | fanconi_pathway | Fanconi anemia pathway |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03460 | Fanconi anemia pathway - Homo sapiens (human) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-73894 | DNA Repair |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD411 | Platinum Agent | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD62 | Platinum | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD49 | Mitomycin | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 5 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD971 | PARP inhibitor | 12 |
| iGMDRD670 | ML 210 | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PALB2
CLASSFICATION
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