PALB2

Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepartner and localizer of BRCA2
OMIM IDMIM:610355
Ensembl IDEnsembl:ENSG00000083093
HGNC IDHGNC:HGNC:26144
PHARMGKB IDPA162398608
Map Location16p12.2

GO terms in PALB2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
BP IDA GO:0000724 double-strand break repair via homologous recombination
BP IMP GO:0000724 double-strand break repair via homologous recombination
BP IEA GO:0001756 somitogenesis
BP IEA GO:0001833 inner cell mass cell proliferation
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Gene expression in normal tissue: PALB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined15Cell cycle1DNA replication1Ferroptosis1Longevity regulating pathway1Drug metabolism - cytochrome P4501Th17 cell differentiation1Chromatin other1Other, kinases1ERK MAPK signaling1

Pathways in PALB2


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Database
Pathway ID
Pathway Des.
pid fanconi_pathway Fanconi anemia pathway
kegg hsa03440 Homologous recombination - Homo sapiens (human)
kegg hsa03460 Fanconi anemia pathway - Homo sapiens (human)
reactome R-HSA-5685942 HDR through Homologous Recombination (HRR)
reactome R-HSA-5693532 DNA Double-Strand Break Repair
reactome R-HSA-5693537 Resolution of D-Loop Structures
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD411 Platinum Agent 2
iGMDRD662 JQ-1 2
iGMDRD577 BIX01294 2
iGMDRD506 Fedratinib 8
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PALB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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