iGMDRD411

Canonical SMILES: C1CC(C1)(C(=O)[O-])C(=O)[O-].N.N.[Pt+2]

InChI: InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI Key: OLESAACUTLOWQZ-UHFFFAOYSA-L

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NamePlatinum Agent
Pubchem CID10339200
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 2OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 8PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Cancer model num: 3

Drug-gene pathway enrichments

3reactome: Resolution of D-Loop Structures3reactome: DNA Double-Strand Break Repair3reactome: HDR through Homologous Recombination (HRR)3reactome: Homology Directed Repair3reactome: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)3reactome: DNA Repair3reactome: Homologous DNA Pairing and Strand Exchange3reactome: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)3reactome: Cell Cycle3reactome: Resolution of D-loop Structures through Holliday Junction Intermediates

Drug-gene GO enrichments

7BP: double-strand break repair via homologous recombination6CC: nucleoplasm5BP: positive regulation of transcription, DNA-templated4MF: protein binding3CC: nucleus3CC: lateral element3BP: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator3BP: double-strand break repair3BP: inner cell mass cell proliferation3BP: positive regulation of transcription by RNA polymerase II

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
672 BRCA1 6
675 BRCA2 7
79728 PALB2 2
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Gene in drug-gene network: Network Plot

PX 12PX 12BMS-536924BMS-536924isoevodiamineisoevodiamineGW-843682XGW-843682XABT-751ABT-751nakiterpiosinnakiterpiosinleucascandrolide Aleucascandrolide APARP inhibitorsPARP inhibitorsNsc 632839Nsc 632839OlaparibOlaparibpevonedistatpevonedistatindisulamindisulamFQI-2FQI-2CHM-1CHM-1BRCA2BRCA2IdarubicinIdarubicinquinoclaminequinoclamineparbendazoleparbendazoleMerck60Merck60FedratinibFedratinibRucaparibRucaparibchemotherapychemotherapyCompound 10b [PMID: 11504634]Compound 10b [PMID: 11504634]PAC-1PAC-1LexibulinLexibulinBRCA1BRCA1kinetin ribosidekinetin ribosidePRL-3 Inhibitor IPRL-3 Inhibitor IML 210ML 210TamoxifenTamoxifenMytomycin CMytomycin C(1S,3R)-RSL3(1S,3R)-RSL3PALB2PALB2platinum agentsplatinum agents

Models in Platinum Agent

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
ONCO-MUT(BRCA1) gene 25847936 BREAST Invasive Breast Carcinoma (BRCA) Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA1) gene 22406760 OVARY Ovarian Cancer Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA1) gene 22711857 OVARY Ovarian Cancer Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA2) gene 25847936 BREAST Invasive Breast Carcinoma (BRCA) Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA2) gene 22406760 OVARY Ovarian Cancer Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA2) gene 22711857 OVARY Ovarian Cancer Platinum Agent sensitivity in vivo
ONCO-MUT(BRCA2) gene 25719666 PANCREAS Pancreatic Cancer Platinum Agent sensitivity in vivo
ONCO-MUT(PALB2) gene 25719666 PANCREAS Pancreatic Cancer Platinum Agent sensitivity in vivo
DEL(PALB2) gene 25719666 PANCREAS Pancreatic Cancer Platinum Agent sensitivity in vivo
MUT(BRCA1) gene 25847936 BREAST Breast Carcinoma platinum agents sensitivity in vivo
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