BRCA2


Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
BRCA2, DNA repair associatedMIM:600185Ensembl:ENSG00000139618HGNC:HGNC:1101PA2541213q13.1

GO terms in BRCA2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0002020protease binding
MFIPIGO:0002020protease binding
MFIBAGO:0003697single-stranded DNA binding
MFIDAGO:0003697single-stranded DNA binding
MFIBAGO:0004402histone acetyltransferase activity
MFIDAGO:0004402histone acetyltransferase activity
MFIBAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIBAGO:0008022protein C-terminus binding
MFIDAGO:0008022protein C-terminus binding
MFIDAGO:0010484H3 histone acetyltransferase activity
MFIDAGO:0010485H4 histone acetyltransferase activity
MFIBAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0043015gamma-tubulin binding
MFIPIGO:0043015gamma-tubulin binding
CCIBAGO:0000784nuclear chromosome, telomeric region
CCIDAGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0000800lateral element
CCIDAGO:0000800lateral element
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIBAGO:0005654nucleoplasm
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005813centrosome
CCIDAGO:0005813centrosome
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIBAGO:0030141secretory granule
CCIDAGO:0030141secretory granule
CCIDAGO:0032991protein-containing complex
CCIBAGO:0033593BRCA2-MAGE-D1 complex
CCIDAGO:0033593BRCA2-MAGE-D1 complex
BPIDAGO:0000281mitotic cytokinesis
BPIBAGO:0000722telomere maintenance via recombination
BPIEAGO:0000722telomere maintenance via recombination
BPIBAGO:0000724double-strand break repair via homologous recombination
BPIDAGO:0000724double-strand break repair via homologous recombination
BPIMPGO:0000724double-strand break repair via homologous recombination
BPIBAGO:0001556oocyte maturation
BPIEAGO:0001556oocyte maturation
BPIBAGO:0001833inner cell mass cell proliferation
BPIEAGO:0001833inner cell mass cell proliferation
BPIBAGO:0006289nucleotide-excision repair
BPIMPGO:0006289nucleotide-excision repair
BPIMPGO:0006302double-strand break repair
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BPIEAGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BPIBAGO:0007141male meiosis I
BPIEAGO:0007141male meiosis I
BPIBAGO:0007283spermatogenesis
BPIEAGO:0007283spermatogenesis
BPIBAGO:0007420brain development
BPIEAGO:0007420brain development
BPIEAGO:0007569cell aging
BPIBAGO:0007584response to nutrient
BPIBAGO:0008585female gonad development
BPIEAGO:0008585female gonad development
BPIBAGO:0010165response to X-ray
BPIEAGO:0010165response to X-ray
BPIBAGO:0010225response to UV-C
BPIEAGO:0010225response to UV-C
BPIBAGO:0010332response to gamma radiation
BPIEAGO:0010332response to gamma radiation
BPIBAGO:0010778meiotic DNA repair synthesis involved in reciprocal meiotic recombination
BPIBAGO:0030097hemopoiesis
BPIEAGO:0030097hemopoiesis
BPIBAGO:0030879mammary gland development
BPIBAGO:0031619homologous chromosome orientation involved in meiotic metaphase I plate congression
BPIBAGO:0032355response to estradiol
BPIBAGO:0032465regulation of cytokinesis
BPIEAGO:0032465regulation of cytokinesis
BPIBAGO:0033600negative regulation of mammary gland epithelial cell proliferation
BPIDAGO:0033600negative regulation of mammary gland epithelial cell proliferation
BPIBAGO:0035264multicellular organism growth
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIEAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPIBAGO:0043150DNA synthesis involved in double-strand break repair via homologous recombination
BPIBAGO:0043966histone H3 acetylation
BPIDAGO:0043966histone H3 acetylation
BPIBAGO:0043967histone H4 acetylation
BPIDAGO:0043967histone H4 acetylation
BPIBAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045931positive regulation of mitotic cell cycle
BPIEAGO:0045931positive regulation of mitotic cell cycle
BPIBAGO:0048478replication fork protection
BPIEAGO:0048478replication fork protection
BPIBAGO:0051298centrosome duplication
BPIMPGO:0051298centrosome duplication
BPIBAGO:0051598meiotic recombination checkpoint
BPIBAGO:0070200establishment of protein localization to telomere
BPIDAGO:0070200establishment of protein localization to telomere
BPIBAGO:1990426mitotic recombination-dependent replication fork processing
BPIMPGO:1990426mitotic recombination-dependent replication fork processing

Gene expression in normal tissue: BRCA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRCA2


DatabasePathway IDPathway Des.
wikipathwaysWP186Homologous recombination
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
pidatr_pathwayATR signaling pathway
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidfanconi_pathwayFanconi anemia pathway
pidfoxm1pathwayFOXM1 transcription factor network
pidp73pathwayp73 transcription factor network
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa03460Fanconi anemia pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
biocartaatrbrcapathwayrole of brca1 brca2 and atr in cancer susceptibility
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-912446Meiotic recombination

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD151CHM-17
iGMDRD433Lexibulin4
iGMDRD76Simvastatin2
iGMDRD126Tipifarnib3
iGMDRD420Leucascandrolide A6
iGMDRD889Compound 7d-cis3
iGMDRD670ML 2103
iGMDRD779PRL-3 Inhibitor I2
iGMDRD974PD1 blockade1
iGMDRD639YK 4-2794
iGMDRD466Chaetocin4
iGMDRD260FQI-27
iGMDRD171Pemetrexed2
iGMDRD187BRD98763
iGMDRD399Selumetinib2
iGMDRD74Idarubicin2
iGMDRD188Piperlongumine4
iGMDRD146Elesclomol1
iGMDRD190Nilotinib1
iGMDRD64Parbendazole3
iGMDRD369TGX-1152
iGMDRD23Gossypol3
iGMDRD532Olaparib18
iGMDRD150RITA4
iGMDRD405PIK-752
iGMDRD583LDN 1931891
iGMDRD50Cytarabine1
iGMDRD49Mitomycin1
iGMDRD341Triacsin c1
iGMDRD237ABT-7516
iGMDRD383Cediranib1
iGMDRD123Isoevodiamine6
iGMDRD879chemotherapy4
iGMDRD945ML2144
iGMDRD883CIL55A2
iGMDRD154NSC237662
iGMDRD137Indisulam7
iGMDRD121GMX17782
iGMDRD103SN-384
iGMDRD402AKT Inhibitor VIII1
iGMDRD288Carboplatin1
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin8
iGMDRD105Triptolide1
iGMDRD871BRD63681
iGMDRD286Nsc 6328396
iGMDRD552AZD-17752
iGMDRD263AACOCF33
iGMDRD1008SR-II-138A2
iGMDRD387CHIR-990213
iGMDRD971PARP inhibitor7
iGMDRD494Neopeltolide2
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD446LY 21832403
iGMDRD193Fqi14
iGMDRD280CYTOCHALASIN B1
iGMDRD401Afatinib1
iGMDRD138PX 125
iGMDRD109Gefitinib1
iGMDRD255SB2250022
iGMDRD8024-methylfasudil3
iGMDRD782DC-45-A22
iGMDRD973PD1 Ab inhibitor1
iGMDRD30917AAG1
iGMDRD441TW 373
iGMDRD100Zebularine3
iGMDRD577BIX012942
iGMDRD411Platinum Agent7
iGMDRD451Serdemetan4
iGMDRD486Tosedostat2
iGMDRD512nutlin 33
iGMDRD299ICL 6701
iGMDRD160Cis-Platin3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD536PLX-47201
iGMDRD351GW843682X7
iGMDRD901ELCPK3
iGMDRD211(1S,3R)-RSL33
iGMDRD435BI-25362
iGMDRD479Veliparib2
iGMDRD434BMS-5369248
iGMDRD62Platinum2
iGMDRD381Rucaparib2
iGMDRD504Obatoclax1
iGMDRD872BRD71371
iGMDRD414MST-3121
iGMDRD246NPC263
iGMDRD505Pevonedistat6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRCA2

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