DAPK2
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| death associated protein kinase 2 | MIM:616567 | Ensembl:ENSG00000035664 | HGNC:HGNC:2675 | PA27143 | 15q22.31 |
GO terms in DAPK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IBA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0034423 | autophagosome lumen |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0010506 | regulation of autophagy |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IMP | GO:0043276 | anoikis |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0090023 | positive regulation of neutrophil chemotaxis |
| BP | IEA | GO:1990266 | neutrophil migration |
| BP | IMP | GO:2000424 | positive regulation of eosinophil chemotaxis |
| BP | IMP | GO:2001242 | regulation of intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: DAPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DAPK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| wikipathways | WP2828 | Bladder Cancer |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DAPK2
CLASSFICATION
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