DAPK2


Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
death associated protein kinase 2MIM:616567Ensembl:ENSG00000035664HGNC:HGNC:2675PA2714315q22.31

GO terms in DAPK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFIBAGO:0005524ATP binding
MFIDAGO:0005524ATP binding
MFIPIGO:0042802identical protein binding
CCIBAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0031410cytoplasmic vesicle
CCIEAGO:0034423autophagosome lumen
CCIDAGO:0043231intracellular membrane-bounded organelle
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006915apoptotic process
BPTASGO:0010506regulation of autophagy
BPIDAGO:0035556intracellular signal transduction
BPTASGO:0042981regulation of apoptotic process
BPIMPGO:0043276anoikis
BPTASGO:0046777protein autophosphorylation
BPIMPGO:0090023positive regulation of neutrophil chemotaxis
BPIEAGO:1990266neutrophil migration
BPIMPGO:2000424positive regulation of eosinophil chemotaxis
BPIMPGO:2001242regulation of intrinsic apoptotic signaling pathway

Gene expression in normal tissue: DAPK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DAPK2


DatabasePathway IDPathway Des.
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
wikipathwaysWP2828Bladder Cancer
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-418889via Dependence Receptors in the absence of ligand
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357801Programmed Cell Death

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid3
iGMDRD499PDMP3
iGMDRD444Tivantinib3
iGMDRD883CIL55A3
iGMDRD945ML2143
iGMDRD221Tamoxifen3
iGMDRD289Parthenolide1
iGMDRD483SCH-5290743
iGMDRD318PAC-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DAPK2

​​​​