NEK1


Summary: The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
NIMA related kinase 1MIM:604588Ensembl:ENSG00000137601HGNC:HGNC:7744PA315454q33

GO terms in NEK1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007049cell cycle
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPIMPGO:0042769DNA damage response, detection of DNA damage
BPIEAGO:0051301cell division
BPIMPGO:0060271cilium assembly
CCIDAGO:0000242pericentriolar material
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIMPGO:0016301kinase activity
MFIEAGO:0046872metal ion binding
MFISSGO:007188914-3-3 protein binding

Gene expression in normal tissue: NEK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEK1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD123Isoevodiamine7
iGMDRD154NSC237663
iGMDRD314Tanespimycin1
iGMDRD237ABT-7513
iGMDRD532Olaparib3
iGMDRD150RITA2
iGMDRD405PIK-751
iGMDRD248BRD43543
iGMDRD147Prima-13
iGMDRD871BRD63684
iGMDRD367Ro 28-16753
iGMDRD329Merck602
iGMDRD221Tamoxifen3
iGMDRD289Parthenolide2
iGMDRD213SMR0000686503
iGMDRD121GMX17782
iGMDRD679Bistramide A2
iGMDRD466Chaetocin2
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD61Kinetin riboside2
iGMDRD793BEC (hydrochloride)3
iGMDRD546BMS-7548072
iGMDRD483SCH-5290746
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib8
iGMDRD433Lexibulin3
iGMDRD889Compound 7d-cis1
iGMDRD425ERASTIN3
iGMDRD369TGX-1153
iGMDRD64Parbendazole7
iGMDRD356PNU-746542
iGMDRD23Gossypol1
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib2
iGMDRD74Idarubicin4
iGMDRD730Kahalalide F3
iGMDRD506Fedratinib3
iGMDRD780PP-305
iGMDRD171Pemetrexed3
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD187BRD98765
iGMDRD901ELCPK4
iGMDRD424Tamatinib3
iGMDRD84Lovastatin acid2
iGMDRD307Manumycin A3
iGMDRD512nutlin 31
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib1
iGMDRD872BRD71375
iGMDRD6AM-5803
iGMDRD192CIL563
iGMDRD434BMS-5369242
iGMDRD415LE-1353
iGMDRD280CYTOCHALASIN B5
iGMDRD375GW-4058333
iGMDRD163all trans Retinoic Acid3
iGMDRD193Fqi14
iGMDRD144NSC953976
iGMDRD579PF7505
iGMDRD1008SR-II-138A2
iGMDRD690PRIMA-1MET3
iGMDRD268Cerulenin2
iGMDRD598QS-113
iGMDRD451Serdemetan2
iGMDRD100Zebularine3
iGMDRD577BIX012942
iGMDRD398Sepantronium3
iGMDRD562Navitoclax4
iGMDRD782DC-45-A27
iGMDRD138PX 123
iGMDRD8024-methylfasudil8
iGMDRD255SB2250024

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK1

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