NEK1
Summary: The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 1 | MIM:604588 | Ensembl:ENSG00000137601 | HGNC:HGNC:7744 | PA31545 | 4q33 |
GO terms in NEK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | IEA | GO:0051301 | cell division |
| BP | IMP | GO:0060271 | cilium assembly |
| CC | IDA | GO:0000242 | pericentriolar material |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IMP | GO:0016301 | kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | ISS | GO:0071889 | 14-3-3 protein binding |
Gene expression in normal tissue: NEK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 7 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD793 | BEC (hydrochloride) | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 5 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD163 | all trans Retinoic Acid | 3 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD579 | PF750 | 5 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD598 | QS-11 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD782 | DC-45-A2 | 7 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD802 | 4-methylfasudil | 8 |
| iGMDRD255 | SB225002 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK1
CLASSFICATION
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