TAF15


Summary: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

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Gene Categories:

DRUGGABLE GENOME

GO terms in TAF15


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005730 nucleolus
CC IDA GO:0005737 cytoplasm
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Gene expression in normal tissue: TAF15

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined30Apoptosis regulation3Drug metabolism - cytochrome P4501DNA replication1Mitosis1Ferroptosis1Biosynthesis of secondary metabolites1Longevity regulating pathway1Arachidonic acid metabolism1Metabolic pathways1

Pathways in TAF15


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Database
Pathway ID
Pathway Des.
kegg hsa03022 Basal transcription factors - Homo sapiens (human)
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
reactome R-HSA-162587 HIV Life Cycle
reactome R-HSA-162599 Late Phase of HIV Life Cycle
reactome R-HSA-162906 HIV Infection
reactome R-HSA-1643685 Disease
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD670 ML 210 2
iGMDRD494 Neopeltolide 2
iGMDRD781 Sirolimus 5
iGMDRD126 Tipifarnib 9
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAF15

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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