TAF15
Summary: This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TATA-box binding protein associated factor 15 | MIM:601574 | Ensembl:ENSG00000270647 | HGNC:HGNC:11547 | PA36322 | 17q12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in TAF15
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003712 | transcription coregulator activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: TAF15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAF15
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03022 | Basal transcription factors - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-167161 | HIV Transcription Initiation |
| reactome | R-HSA-167162 | RNA Polymerase II HIV Promoter Escape |
| reactome | R-HSA-167172 | Transcription of the HIV genome |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-674695 | RNA Polymerase II Pre-transcription Events |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73776 | RNA Polymerase II Promoter Escape |
| reactome | R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75953 | RNA Polymerase II Transcription Initiation |
| reactome | R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD670 | ML 210 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD126 | Tipifarnib | 9 |
| iGMDRD554 | CHEMBL1434137 | 5 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD299 | ICL 670 | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAF15
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