HSPB8


Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heat shock protein family B (small) member 8MIM:608014Ensembl:ENSG00000152137HGNC:HGNC:30171PA13490017312q24.23

GO terms in HSPB8


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005622intracellular
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
BPNDGO:0008150biological_process
BPTASGO:1900034regulation of cellular response to heat
MFIDAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: HSPB8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSPB8


DatabasePathway IDPathway Des.
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD100Zebularine3
iGMDRD871BRD63682
iGMDRD74Idarubicin3
iGMDRD872BRD71372
iGMDRD888Compound 443
iGMDRD505Pevonedistat2
iGMDRD246NPC263
iGMDRD451Serdemetan2
iGMDRD138PX 123
iGMDRD8024-methylfasudil3
iGMDRD289Parthenolide3
iGMDRD221Tamoxifen3
iGMDRD171Pemetrexed6
iGMDRD267Oligomycin A3
iGMDRD52Rotenone3
iGMDRD77Itraconazole3
iGMDRD85Ursolic acid3
iGMDRD466Chaetocin3
iGMDRD280CYTOCHALASIN B2
iGMDRD945ML2143
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD511CHEMBL3993793
iGMDRD126Tipifarnib4
iGMDRD330BRD41323
iGMDRD512nutlin 31
iGMDRD599Salermide6
iGMDRD889Compound 7d-cis2
iGMDRD772BRD47705
iGMDRD494Neopeltolide3
iGMDRD405PIK-753
iGMDRD652UNC06383

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPB8

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