HSPB8
Summary: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family B (small) member 8 | MIM:608014 | Ensembl:ENSG00000152137 | HGNC:HGNC:30171 | PA134900173 | 12q24.23 |
GO terms in HSPB8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | ND | GO:0008150 | biological_process |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: HSPB8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPB8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD171 | Pemetrexed | 6 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD652 | UNC0638 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPB8
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