BCL11A


Summary: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
B cell CLL/lymphoma 11AMIM:606557Ensembl:ENSG00000119866HGNC:HGNC:13221PA253002p16.1

GO terms in BCL11A


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIBAGO:0043565sequence-specific DNA binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046872metal ion binding
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0007275multicellular organism development
BPISSGO:0016925protein sumoylation

Gene expression in normal tissue: BCL11A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL11A


DatabasePathway IDPathway Des.
wikipathwaysWP3995Prion disease pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD251ML1621
iGMDRD202Curcumin3
iGMDRD137Indisulam6
iGMDRD289Parthenolide4
iGMDRD221Tamoxifen2
iGMDRD329Merck603
iGMDRD286Nsc 6328394
iGMDRD871BRD63681
iGMDRD414MST-3123
iGMDRD353PD03259011
iGMDRD148Pifithrin-mu2
iGMDRD512nutlin 33
iGMDRD405PIK-753
iGMDRD79Gemcitabine5
iGMDRD150RITA4
iGMDRD237ABT-7511
iGMDRD499PDMP1
iGMDRD85Ursolic acid4
iGMDRD568SCHEMBL150055121
iGMDRD255SB2250023
iGMDRD298L-6854582
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD782DC-45-A23
iGMDRD562Navitoclax5
iGMDRD188Piperlongumine4
iGMDRD126Tipifarnib3
iGMDRD483SCH-5290742
iGMDRD61Kinetin riboside2
iGMDRD446LY 21832402
iGMDRD634SCHEMBL26080413
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL11A

​​​​