BCL11A
Summary: This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| B cell CLL/lymphoma 11A | MIM:606557 | Ensembl:ENSG00000119866 | HGNC:HGNC:13221 | PA25300 | 2p16.1 |
GO terms in BCL11A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0016925 | protein sumoylation |
Gene expression in normal tissue: BCL11A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD251 | ML162 | 1 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD79 | Gemcitabine | 5 |
| iGMDRD150 | RITA | 4 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD568 | SCHEMBL15005512 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD298 | L-685458 | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL11A
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