PDGFRB


Summary: The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
platelet derived growth factor receptor betaMIM:173410Ensembl:ENSG00000113721HGNC:HGNC:8804PA331485q32

GO terms in PDGFRB


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFTASGO:0004992platelet activating factor receptor activity
MFIBAGO:0005017platelet-derived growth factor-activated receptor activity
MFTASGO:0005017platelet-derived growth factor-activated receptor activity
MFIBAGO:0005019platelet-derived growth factor beta-receptor activity
MFIDAGO:0005019platelet-derived growth factor beta-receptor activity
MFIMPGO:0005019platelet-derived growth factor beta-receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0019838growth factor binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019901protein kinase binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0038085vascular endothelial growth factor binding
MFIEAGO:0043548phosphatidylinositol 3-kinase binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIBAGO:0048407platelet-derived growth factor binding
MFIDAGO:0048407platelet-derived growth factor binding
MFIPIGO:0048407platelet-derived growth factor binding
BPTASGO:0000165MAPK cascade
BPIEAGO:0006024glycosaminoglycan biosynthetic process
BPIDAGO:0007165signal transduction
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007568aging
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0008584male gonad development
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0010863positive regulation of phospholipase C activity
BPISSGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIMPGO:0014911positive regulation of smooth muscle cell migration
BPISSGO:0014911positive regulation of smooth muscle cell migration
BPIMPGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIDAGO:0030335positive regulation of cell migration
BPIEAGO:0032355response to estradiol
BPIDAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIEAGO:0032526response to retinoic acid
BPISSGO:0032956regulation of actin cytoskeleton organization
BPIEAGO:0032967positive regulation of collagen biosynthetic process
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0034405response to fluid shear stress
BPIEAGO:0035025positive regulation of Rho protein signal transduction
BPISSGO:0035441cell migration involved in vasculogenesis
BPIEAGO:0035789metanephric mesenchymal cell migration
BPIMPGO:0035791platelet-derived growth factor receptor-beta signaling pathway
BPISSGO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
BPISSGO:0035909aorta morphogenesis
BPIEAGO:0036120cellular response to platelet-derived growth factor stimulus
BPIBAGO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
BPIDAGO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
BPIEAGO:0042060wound healing
BPIEAGO:0042542response to hydrogen peroxide
BPIEAGO:0043065positive regulation of apoptotic process
BPIBAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043066negative regulation of apoptotic process
BPISSGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0043552positive regulation of phosphatidylinositol 3-kinase activity
BPIEAGO:0043627response to estrogen
BPISSGO:0045840positive regulation of mitotic nuclear division
BPIMPGO:0046488phosphatidylinositol metabolic process
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIDAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIMPGO:0048015phosphatidylinositol-mediated signaling
BPIEAGO:0048146positive regulation of fibroblast proliferation
BPIMPGO:0048661positive regulation of smooth muscle cell proliferation
BPISSGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0048839inner ear development
BPISSGO:0050921positive regulation of chemotaxis
BPTASGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0055003cardiac myofibril assembly
BPIEAGO:0055093response to hyperoxia
BPIDAGO:0060326cell chemotaxis
BPIEAGO:0060437lung growth
BPISSGO:0060981cell migration involved in coronary angiogenesis
BPISSGO:0061298retina vasculature development in camera-type eye
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0071670smooth muscle cell chemotaxis
BPIEAGO:0072075metanephric mesenchyme development
BPISSGO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros development
BPISSGO:0072277metanephric glomerular capillary formation
BPIEAGO:0072278metanephric comma-shaped body morphogenesis
BPIEAGO:0072284metanephric S-shaped body morphogenesis
BPISSGO:0090280positive regulation of calcium ion import
BPISSGO:2000379positive regulation of reactive oxygen species metabolic process
BPIEAGO:2000491positive regulation of hepatic stellate cell activation
BPISSGO:2000573positive regulation of DNA biosynthetic process
CCISSGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0009986cell surface
CCHDAGO:0016020membrane
CCIDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCISSGO:0016324apical plasma membrane
CCIDAGO:0031226intrinsic component of plasma membrane
CCIEAGO:0031410cytoplasmic vesicle
CCIEAGO:0043202lysosomal lumen
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIBAGO:0043235receptor complex

Gene expression in normal tissue: PDGFRB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDGFRB


DatabasePathway IDPathway Des.
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2526PDGF Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP322Osteoblast Signaling
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
pidintegrin3_pathwayBeta3 integrin cell surface interactions
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidnectin_pathwayNectin adhesion pathway
pidpdgf_pathwayPDGF receptor signaling network
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pids1p_s1p1_pathwayS1P1 pathway
pids1p_s1p3_pathwayS1P3 pathway
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD524ISX-96
iGMDRD602Foretinib1
iGMDRD356PNU-746543
iGMDRD23Gossypol1
iGMDRD64Parbendazole1
iGMDRD340SU 112741
iGMDRD506Fedratinib3
iGMDRD349Lenvatinib1
iGMDRD188Piperlongumine4
iGMDRD52Rotenone3
iGMDRD117Docetaxel1
iGMDRD994QW-BI-0111
iGMDRD260FQI-21
iGMDRD474Avrainvillamide6
iGMDRD513BML-2593
iGMDRD259EX-5271
iGMDRD760ML2391
iGMDRD639YK 4-2791
iGMDRD781Sirolimus2
iGMDRD484Pluripotin1
iGMDRD75Lovastatin1
iGMDRD397Pazopanib1
iGMDRD779PRL-3 Inhibitor I1
iGMDRD670ML 2101
iGMDRD427ABT7376
iGMDRD420Leucascandrolide A6
iGMDRD889Compound 7d-cis3
iGMDRD249CCT0364771
iGMDRD151CHM-11
iGMDRD526KX2-3911
iGMDRD147Prima-13
iGMDRD329Merck605
iGMDRD119Temsirolimus1
iGMDRD871BRD63686
iGMDRD327LBH-5891
iGMDRD197DBeQ1
iGMDRD77Itraconazole3
iGMDRD244ML3111
iGMDRD186SMER31
iGMDRD705Nakiterpiosin1
iGMDRD221Tamoxifen1
iGMDRD289Parthenolide1
iGMDRD439KW-24491
iGMDRD787PF 1841
iGMDRD228ML0291
iGMDRD121GMX17783
iGMDRD251ML1621
iGMDRD123Isoevodiamine1
iGMDRD841BRD-A057157091
iGMDRD170Fluvastatin1
iGMDRD540Alisertib1
iGMDRD548Marinopyrrole A1
iGMDRD108CI-9761
iGMDRD242ML0501
iGMDRD50Cytarabine1
iGMDRD423AT 78671
iGMDRD150RITA1
iGMDRD681SB-7439211
iGMDRD532Olaparib1
iGMDRD304CH 551
iGMDRD444Tivantinib2
iGMDRD131Erlotinib1
iGMDRD60Quinoclamine5
iGMDRD533HSCI1_0002701
iGMDRD842BRD-A718831111
iGMDRD577BIX012948
iGMDRD609BRD-K664538931
iGMDRD55Pyrazolanthrone1
iGMDRD637BRD-K373903321
iGMDRD574Ruxolitinib1
iGMDRD1037X1S.3R.RSL.31
iGMDRD261OSI-0271
iGMDRD885Compound 1103
iGMDRD318PAC-15
iGMDRD846BRD-K246903021
iGMDRD134Sorafenib1
iGMDRD255SB2250021
iGMDRD613CHEMBL2581481
iGMDRD422Regorafenib1
iGMDRD320PIK-931
iGMDRD270Ciclosporin2
iGMDRD697Methylstat1
iGMDRD359OSW-13
iGMDRD66Doxorubicin1
iGMDRD528rigosertib1
iGMDRD797ISOX DUAL1
iGMDRD258SB-4315421
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD489GSK-4613641
iGMDRD144NSC953973
iGMDRD772BRD47703
iGMDRD313Axitinib1
iGMDRD685AZD45471
iGMDRD502AZD14801
iGMDRD42Vorinostat3
iGMDRD246NPC265
iGMDRD882CIL411
iGMDRD872BRD71379
iGMDRD267Oligomycin A1
iGMDRD415LE-1351
iGMDRD68Paclitaxel1
iGMDRD6AM-5801
iGMDRD435BI-25361
iGMDRD426WP11301
iGMDRD750TRIAZOLOTHIADIAZINE1
iGMDRD492HBX-411081
iGMDRD346Nintedanib1
iGMDRD765BRD-K514902541
iGMDRD351GW843682X1
iGMDRD410Ko-1433
iGMDRD798Ceranib-21

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDGFRB

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