EPHA8
Summary: This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor A8 | MIM:176945 | Ensembl:ENSG00000070886 | HGNC:HGNC:3391 | PA27823 | 1p36.12 |
GO terms in EPHA8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006929 | substrate-dependent cell migration |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007411 | axon guidance |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | ISS | GO:0016322 | neuron remodeling |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030155 | regulation of cell adhesion |
| BP | ISS | GO:0031175 | neuron projection development |
| BP | ISS | GO:0033628 | regulation of cell adhesion mediated by integrin |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | ISS | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0005004 | GPI-linked ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
Gene expression in normal tissue: EPHA8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHA8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| pid | epha_fwdpathway | EPHA forward signaling |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD698 | Neratinib | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD387 | CHIR-99021 | 4 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD630 | ML203 | 3 |
| iGMDRD640 | CAY10618 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD513 | BML-259 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHA8
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