MAP2K3
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 3 | MIM:602315 | Ensembl:ENSG00000034152 | HGNC:HGNC:6843 | PA30588 | 17p11.2 |
GO terms in MAP2K3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004708 | MAP kinase kinase activity |
| MF | IEA | GO:0004708 | MAP kinase kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0038066 | p38MAPK cascade |
| BP | IEA | GO:0042035 | regulation of cytokine biosynthetic process |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0060048 | cardiac muscle contraction |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: MAP2K3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL1 | IL1 |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TSH | TSH |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-5210891 | Uptake and function of anthrax toxins |
| reactome | R-HSA-5339562 | Uptake and actions of bacterial toxins |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | 41bbpathway | the 41bb-dependent immune response |
| biocarta | fmlppathway | fmlp induced chemokine gene expression in hmc-1 cells |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nthipathway | nfkb activation by nontypeable hemophilus influenzae |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tollpathway | toll-like receptor pathway |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | anthraxpathway | Cellular roles of Anthrax toxin |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | p38gammadeltapathway | Signaling mediated by p38-gamma and p38-delta |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD782 | DC-45-A2 | 8 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD474 | Avrainvillamide | 7 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD375 | GW-405833 | 9 |
| iGMDRD466 | Chaetocin | 6 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD483 | SCH-529074 | 5 |
| iGMDRD579 | PF750 | 6 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD150 | RITA | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K3
CLASSFICATION
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