WLS
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| wntless Wnt ligand secretion mediator | MIM:611514 | Ensembl:ENSG00000116729 | HGNC:HGNC:30238 | PA165752781 | 1p31.3 |
GO terms in WLS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | IPI | GO:0017147 | Wnt-protein binding |
| MF | ISS | GO:0017147 | Wnt-protein binding |
| MF | IEA | GO:0031852 | mu-type opioid receptor binding |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005769 | early endosome |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0012505 | endomembrane system |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | IBA | GO:0031301 | integral component of organelle membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | TAS | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0032590 | dendrite membrane |
| CC | IEA | GO:0032839 | dendrite cytoplasm |
| CC | TAS | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006886 | intracellular protein transport |
| BP | ISS | GO:0009948 | anterior/posterior axis specification |
| BP | ISS | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | IMP | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IEA | GO:0030902 | hindbrain development |
| BP | IEA | GO:0031017 | exocrine pancreas development |
| BP | ISS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0061355 | Wnt protein secretion |
| BP | IMP | GO:0061355 | Wnt protein secretion |
| BP | IMP | GO:0061357 | positive regulation of Wnt protein secretion |
| BP | ISS | GO:0061357 | positive regulation of Wnt protein secretion |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
Gene expression in normal tissue: WLS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WLS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-3238698 | WNT ligand biogenesis and trafficking |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD67 | PENFLURIDOL | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WLS
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.