CYFIP1
Summary: This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606322 Ensembl IDEnsembl:ENSG00000273749 HGNC IDHGNC:HGNC:13759 PHARMGKB IDPA38367 Map Location15q11.2 | |||||
GO terms in CYFIP1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | IEA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IMP | GO:0044877 | protein-containing complex binding |
| MF | IMP | GO:0048365 | Rac GTPase binding |
Gene expression in normal tissue: CYFIP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CYFIP1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TCR | TCR |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| wikipathways | WP524 | G13 Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CYFIP1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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