GUCY2F
Summary: The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| guanylate cyclase 2F, retinal | MIM:300041 | Ensembl:ENSG00000101890 | HGNC:HGNC:4691 | PA29071 | Xq22.3-q23 |
GO terms in GUCY2F
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004016 | adenylate cyclase activity |
| MF | IBA | GO:0004383 | guanylate cyclase activity |
| MF | TAS | GO:0004383 | guanylate cyclase activity |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | TAS | GO:0005640 | nuclear outer membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0008074 | guanylate cyclase complex, soluble |
| CC | TAS | GO:0097381 | photoreceptor disc membrane |
| BP | IBA | GO:0006182 | cGMP biosynthetic process |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007168 | receptor guanylyl cyclase signaling pathway |
| BP | TAS | GO:0007601 | visual perception |
| BP | IBA | GO:0009190 | cyclic nucleotide biosynthetic process |
| BP | TAS | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0050908 | detection of light stimulus involved in visual perception |
Gene expression in normal tissue: GUCY2F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GUCY2F
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cone_pathway | Visual signal transduction: Cones |
| pid | rhodopsin_pathway | Visual signal transduction: Rods |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa04744 | Phototransduction - Homo sapiens (human) |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD247 | Blebbistatin | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GUCY2F
CLASSFICATION
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