MSH3
Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mutS homolog 3 | MIM:600887 | Ensembl:ENSG00000113318 | HGNC:HGNC:7326 | PA31134 | 5q14.1 |
Gene Categories:
DNA REPAIRGO terms in MSH3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0032300 | mismatch repair complex |
| CC | IBA | GO:0032302 | MutSbeta complex |
| CC | IDA | GO:0032302 | MutSbeta complex |
| BP | IBA | GO:0000710 | meiotic mismatch repair |
| BP | IBA | GO:0000735 | removal of nonhomologous ends |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IBA | GO:0006298 | mismatch repair |
| BP | IMP | GO:0006298 | mismatch repair |
| BP | TAS | GO:0006298 | mismatch repair |
| BP | IBA | GO:0006312 | mitotic recombination |
| BP | IBA | GO:0007131 | reciprocal meiotic recombination |
| BP | IBA | GO:0016447 | somatic recombination of immunoglobulin gene segments |
| BP | IBA | GO:0043111 | replication fork arrest |
| BP | IBA | GO:0043570 | maintenance of DNA repeat elements |
| BP | IMP | GO:0043570 | maintenance of DNA repeat elements |
| BP | IDA | GO:0045910 | negative regulation of DNA recombination |
| BP | IBA | GO:0051096 | positive regulation of helicase activity |
| BP | IDA | GO:0051096 | positive regulation of helicase activity |
| MF | IBA | GO:0000403 | Y-form DNA binding |
| MF | IBA | GO:0000404 | heteroduplex DNA loop binding |
| MF | IBA | GO:0000406 | double-strand/single-strand DNA junction binding |
| MF | IBA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003697 | single-stranded DNA binding |
| MF | IDA | GO:0003697 | single-stranded DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IBA | GO:0019237 | centromeric DNA binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0030983 | mismatched DNA binding |
| MF | IDA | GO:0030983 | mismatched DNA binding |
| MF | IDA | GO:0032137 | guanine/thymine mispair binding |
| MF | IDA | GO:0032139 | dinucleotide insertion or deletion binding |
| MF | IBA | GO:0032142 | single guanine insertion binding |
| MF | IDA | GO:0032142 | single guanine insertion binding |
| MF | IBA | GO:0032181 | dinucleotide repeat insertion binding |
| MF | IDA | GO:0032181 | dinucleotide repeat insertion binding |
| MF | IBA | GO:0032357 | oxidized purine DNA binding |
| MF | IDA | GO:0032357 | oxidized purine DNA binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: MSH3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MSH3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-5423599 | Diseases of Mismatch Repair (MMR) |
| reactome | R-HSA-5632927 | Defective Mismatch Repair Associated With MSH3 |
| reactome | R-HSA-5632928 | Defective Mismatch Repair Associated With MSH2 |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73894 | DNA Repair |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 5 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD730 | Kahalalide F | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD690 | PRIMA-1MET | 4 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD268 | Cerulenin | 4 |
| iGMDRD598 | QS-11 | 4 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD579 | PF750 | 5 |
| iGMDRD425 | ERASTIN | 5 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 5 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD163 | all trans Retinoic Acid | 5 |
| iGMDRD793 | BEC (hydrochloride) | 4 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD221 | Tamoxifen | 5 |
| iGMDRD6 | AM-580 | 7 |
| iGMDRD192 | CIL56 | 4 |
| iGMDRD415 | LE-135 | 4 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD213 | SMR000068650 | 5 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD367 | Ro 28-1675 | 4 |
| iGMDRD892 | DNA-PKc inhibitor | 2 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD147 | Prima-1 | 5 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD532 | Olaparib | 5 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD123 | Isoevodiamine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MSH3
CLASSFICATION
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