MSH3

Summary: The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamemutS homolog 3
OMIM IDMIM:600887
Ensembl IDEnsembl:ENSG00000113318
HGNC IDHGNC:HGNC:7326
PHARMGKB IDPA31134
Map Location5q14.1

Gene Categories:

DNA REPAIR

GO terms in MSH3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005654 nucleoplasm
CC HDA GO:0016020 membrane
CC IBA GO:0032300 mismatch repair complex
CC IBA GO:0032302 MutSbeta complex
CC IDA GO:0032302 MutSbeta complex
BP IBA GO:0000710 meiotic mismatch repair
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Gene expression in normal tissue: MSH3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined42Apoptosis regulation2Mitosis1PI3K/MTOR signaling1Genome integrity1Cell cycle1Drug metabolism - cytochrome P4501Terpenoid backbone biosynthesis1ERK MAPK signaling1Other, kinases1

Pathways in MSH3


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Database
Pathway ID
Pathway Des.
kegg hsa03430 Mismatch repair - Homo sapiens (human)
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
kegg hsa05210 Colorectal cancer - Homo sapiens (human)
wikipathways WP4216 Chromosomal and microsatellite instability in colorectal cancer
reactome R-HSA-1643685 Disease
reactome R-HSA-5358508 Mismatch Repair
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
iGMDRD801 2,4-dideoxy-DC-45-A2 5
iGMDRD885 Compound 110 2
iGMDRD318 PAC-1 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSH3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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