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EPHA3

Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
EPH receptor A3	MIM:179611	Ensembl:ENSG00000044524	HGNC:HGNC:3387	PA27819	3p11.1

Gene Categories:

KINASE CLINICALLY ACTIONABLE TYROSINE KINASE DRUGGABLE GENOME

GO terms in EPHA3

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0005576	extracellular region
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005769	early endosome
CC	TAS	GO:0005886	plasma membrane
CC	IBA	GO:0005887	integral component of plasma membrane
CC	IDA	GO:0005887	integral component of plasma membrane
CC	IBA	GO:0043005	neuron projection
CC	IBA	GO:0043235	receptor complex
BP	IEA	GO:0007155	cell adhesion
BP	IBA	GO:0007275	multicellular organism development
BP	IBA	GO:0009968	negative regulation of signal transduction
BP	ISS	GO:0010717	regulation of epithelial to mesenchymal transition
BP	IMP	GO:0010976	positive regulation of neuron projection development
BP	ISS	GO:0016477	cell migration
BP	IDA	GO:0018108	peptidyl-tyrosine phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	IDA	GO:0032956	regulation of actin cytoskeleton organization
BP	IBA	GO:0033674	positive regulation of kinase activity
BP	IBA	GO:0043066	negative regulation of apoptotic process
BP	IDA	GO:0043087	regulation of GTPase activity
BP	IBA	GO:0043410	positive regulation of MAPK cascade
BP	IDA	GO:0045806	negative regulation of endocytosis
BP	IDA	GO:0048013	ephrin receptor signaling pathway
BP	TAS	GO:0048013	ephrin receptor signaling pathway
BP	IDA	GO:0051893	regulation of focal adhesion assembly
BP	IBA	GO:0070374	positive regulation of ERK1 and ERK2 cascade
BP	IDA	GO:0070507	regulation of microtubule cytoskeleton organization
BP	IMP	GO:0071300	cellular response to retinoic acid
BP	ISS	GO:0097155	fasciculation of sensory neuron axon
BP	ISS	GO:0097156	fasciculation of motor neuron axon
BP	IDA	GO:1903078	positive regulation of protein localization to plasma membrane
MF	IBA	GO:0004709	MAP kinase kinase kinase activity
MF	IBA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004714	transmembrane receptor protein tyrosine kinase activity
MF	IBA	GO:0004888	transmembrane signaling receptor activity
MF	IDA	GO:0005004	GPI-linked ephrin receptor activity
MF	IBA	GO:0005005	transmembrane-ephrin receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0031434	mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA3

Database	Pathway ID	Pathway Des.
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP2884	NRF2 pathway
pid	epha_fwdpathway	EPHA forward signaling
netpath	Pathway_TCR	TCR
kegg	hsa04360	Axon guidance - Homo sapiens (human)
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-2682334	EPH-Ephrin signaling
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928663	EPHA-mediated growth cone collapse
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-3928665	EPH-ephrin mediated repulsion of cells
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-422475	Axon guidance

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD138	PX 12	3
iGMDRD474	Avrainvillamide	3
iGMDRD260	FQI-2	6
iGMDRD207	Capsaicin	2
iGMDRD870	BRD63610	3
iGMDRD318	PAC-1	3
iGMDRD441	TW 37	2
iGMDRD398	Sepantronium	3
iGMDRD506	Fedratinib	3
iGMDRD64	Parbendazole	7
iGMDRD60	Quinoclamine	2
iGMDRD444	Tivantinib	1
iGMDRD23	Gossypol	4
iGMDRD903	EPHA3 inhibitor	2
iGMDRD151	CHM-1	9
iGMDRD433	Lexibulin	2
iGMDRD446	LY 2183240	1
iGMDRD152	179324-69-7	1
iGMDRD193	Fqi1	7
iGMDRD61	Kinetin riboside	4
iGMDRD280	CYTOCHALASIN B	8
iGMDRD394	BX-795	2
iGMDRD202	Curcumin	2
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD6	AM-580	2
iGMDRD705	Nakiterpiosin	7
iGMDRD221	Tamoxifen	4
iGMDRD481	Dactolisib	5
iGMDRD882	CIL41	2
iGMDRD67	PENFLURIDOL	2
iGMDRD414	MST-312	5
iGMDRD662	JQ-1	1
iGMDRD329	Merck60	2
iGMDRD246	NPC26	2
iGMDRD886	Compound 1541A	2
iGMDRD300	Tozasertib	1
iGMDRD322	FK 866	2
iGMDRD82	Quiflapon	2
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	2
iGMDRD150	RITA	2
iGMDRD116	CD437	5
iGMDRD583	LDN 193189	1
iGMDRD701	NVP-AUY922	6
iGMDRD698	Neratinib	1
iGMDRD123	Isoevodiamine	6
iGMDRD901	ELCPK	5
iGMDRD132	(-)-gallocatechin-3-O-gallate	2
iGMDRD945	ML214	2
iGMDRD435	BI-2536	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA3

SITE

DATATYPES

CLASSFICATION

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