PRDM16
Summary: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PR/SET domain 16 | MIM:605557 | Ensembl:ENSG00000142611 | HGNC:HGNC:14000 | PA33714 | 1p36.32 |
GO terms in PRDM16
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016235 | aggresome |
| CC | ISS | GO:0017053 | transcriptional repressor complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0022008 | neurogenesis |
| BP | IDA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0034968 | histone lysine methylation |
| BP | IEA | GO:0035019 | somatic stem cell population maintenance |
| BP | ISS | GO:0043457 | regulation of cellular respiration |
| BP | IEA | GO:0043586 | tongue development |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0050872 | white fat cell differentiation |
| BP | ISS | GO:0050873 | brown fat cell differentiation |
| BP | IEA | GO:0060021 | roof of mouth development |
| BP | IEA | GO:0090336 | positive regulation of brown fat cell differentiation |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0046332 | SMAD binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: PRDM16
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRDM16
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
| wikipathways | WP3407 | FTO Obesity Variant Mechanism |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD150 | RITA | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD652 | UNC0638 | 5 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD554 | CHEMBL1434137 | 6 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD579 | PF750 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD61 | Kinetin riboside | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRDM16
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