PRDM16


Summary: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
PR/SET domain 16MIM:605557Ensembl:ENSG00000142611HGNC:HGNC:14000PA337141p36.32

GO terms in PRDM16


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016235aggresome
CCISSGO:0017053transcriptional repressor complex
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0022008neurogenesis
BPIDAGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIMPGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIEAGO:0034968histone lysine methylation
BPIEAGO:0035019somatic stem cell population maintenance
BPISSGO:0043457regulation of cellular respiration
BPIEAGO:0043586tongue development
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0050872white fat cell differentiation
BPISSGO:0050873brown fat cell differentiation
BPIEAGO:0060021roof of mouth development
BPIEAGO:0090336positive regulation of brown fat cell differentiation
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIPIGO:0033613activating transcription factor binding
MFIDAGO:0043565sequence-specific DNA binding
MFIEAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: PRDM16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRDM16


DatabasePathway IDPathway Des.
kegghsa04714Thermogenesis - Homo sapiens (human)
wikipathwaysWP2895Differentiation of white and brown adipocyte
wikipathwaysWP3407FTO Obesity Variant Mechanism
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD221Tamoxifen2
iGMDRD77Itraconazole6
iGMDRD267Oligomycin A2
iGMDRD246NPC262
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat3
iGMDRD872BRD71372
iGMDRD414MST-3125
iGMDRD286Nsc 6328398
iGMDRD871BRD63686
iGMDRD366PI-1032
iGMDRD329Merck607
iGMDRD424Tamatinib5
iGMDRD150RITA2
iGMDRD79Gemcitabine2
iGMDRD405PIK-753
iGMDRD652UNC06385
iGMDRD84Lovastatin acid4
iGMDRD945ML2145
iGMDRD85Ursolic acid3
iGMDRD57Chloropentafluorobenzene3
iGMDRD30917AAG1
iGMDRD255SB2250022
iGMDRD60Quinoclamine2
iGMDRD524ISX-92
iGMDRD23Gossypol1
iGMDRD887Compound 23 citrate4
iGMDRD188Piperlongumine2
iGMDRD562Navitoclax5
iGMDRD506Fedratinib2
iGMDRD888Compound 443
iGMDRD577BIX012943
iGMDRD546BMS-7548072
iGMDRD779PRL-3 Inhibitor I3
iGMDRD427ABT7376
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide2
iGMDRD554CHEMBL14341376
iGMDRD151CHM-12
iGMDRD126Tipifarnib3
iGMDRD579PF7504
iGMDRD280CYTOCHALASIN B3
iGMDRD466Chaetocin2
iGMDRD394BX-7952
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080412
iGMDRD201SKI II1
iGMDRD446LY 21832406
iGMDRD61Kinetin riboside1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDM16

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