PRDM16


Summary: The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605557
PHARMGKB IDPA33714
Map Location1p36.32

GO terms in PRDM16


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0016235 aggresome
CC ISS GO:0017053 transcriptional repressor complex
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Gene expression in normal tissue: PRDM16

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined39Apoptosis regulation1Other, kinases1Longevity regulating pathway1Biosynthesis of secondary metabolites1IGFR signaling1Protein stability and degradation1PI3K/MTOR signaling1Purine metabolism1Chromatin histone methylation1

Pathways in PRDM16


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Database
Pathway ID
Pathway Des.
kegg hsa04714 Thermogenesis - Homo sapiens (human)
wikipathways WP2895 Differentiation of white and brown adipocyte
wikipathways WP3407 FTO Obesity Variant Mechanism
reactome R-HSA-3214841 PKMTs methylate histone lysines
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-4839726 Chromatin organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD221 Tamoxifen 2
iGMDRD77 Itraconazole 6
iGMDRD267 Oligomycin A 2
iGMDRD246 NPC26 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRDM16

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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