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MAP4K3

Summary: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemitogen-activated protein kinase kinase kinase kinase 3 OMIM IDMIM:604921 Ensembl IDEnsembl:ENSG00000011566 HGNC IDHGNC:HGNC:6865 PHARMGKB IDPA30611 Map Location2p22.1

Gene Categories:

KINASE TUMOR SUPPRESSOR SERINE THREONINE KINASE DRUGGABLE GENOME

GO terms in MAP4K3

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IBA	GO:0005737	cytoplasm
BP	IBA	GO:0000165	MAPK cascade
BP	IEA	GO:0000185	activation of MAPKKK activity
BP	IDA	GO:0006468	protein phosphorylation
BP	TAS	GO:0007254	JNK cascade
BP	IBA	GO:0007346	regulation of mitotic cell cycle

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Gene expression in normal tissue: MAP4K3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP4K3

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Database	Pathway ID	Pathway Des.
pid	tnfpathway	TNF receptor signaling pathway
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP481	Insulin Signaling
biocarta	mapkpathway	mapkinase signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD524	ISX-9	3
iGMDRD64	Parbendazole	3
iGMDRD780	PP-30	2
iGMDRD577	BIX01294	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP4K3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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