MAP4K3
Summary: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase kinase 3 | MIM:604921 | Ensembl:ENSG00000011566 | HGNC:HGNC:6865 | PA30611 | 2p22.1 |
GO terms in MAP4K3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0009411 | response to UV |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0034612 | response to tumor necrosis factor |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008349 | MAP kinase kinase kinase kinase activity |
Gene expression in normal tissue: MAP4K3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP4K3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | tnfpathway | TNF receptor signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| biocarta | mapkpathway | mapkinase signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD27 | WHI-P97 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD307 | Manumycin A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP4K3
CLASSFICATION
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