MAP2K5
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 5 | MIM:602520 | Ensembl:ENSG00000137764 | HGNC:HGNC:6845 | PA30590 | 15q23 |
GO terms in MAP2K5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | ISS | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IEA | GO:0030307 | positive regulation of cell growth |
| BP | ISS | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | ISS | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| BP | ISS | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0045415 | negative regulation of interleukin-8 biosynthetic process |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | ISS | GO:0051247 | positive regulation of protein metabolic process |
| BP | ISS | GO:0060761 | negative regulation of response to cytokine stimulus |
| BP | IEA | GO:0070375 | ERK5 cascade |
| BP | ISS | GO:0071363 | cellular response to growth factor stimulus |
| BP | TAS | GO:0071499 | cellular response to laminar fluid shear stress |
| BP | ISS | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | ISS | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production |
| BP | ISS | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | IEA | GO:0005829 | cytosol |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004708 | MAP kinase kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MAP2K5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198765 | Signalling to ERK5 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | mapkpathway | mapkinase signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD67 | PENFLURIDOL | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD221 | Tamoxifen | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K5
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.