MAP2K5
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602520 Ensembl IDEnsembl:ENSG00000137764 HGNC IDHGNC:HGNC:6845 PHARMGKB IDPA30590 Map Location15q23 | |||||
GO terms in MAP2K5
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000187 | activation of MAPK activity |
| BP | ISS | GO:0000187 | activation of MAPK activity |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007507 | heart development |
Gene expression in normal tissue: MAP2K5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP2K5
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP2K5
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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