MAP2K5


Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase 5MIM:602520Ensembl:ENSG00000137764HGNC:HGNC:6845PA3059015q23

GO terms in MAP2K5


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000187activation of MAPK activity
BPISSGO:0000187activation of MAPK activity
BPTASGO:0007165signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0007507heart development
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIEAGO:0030307positive regulation of cell growth
BPISSGO:0032088negative regulation of NF-kappaB transcription factor activity
BPIBAGO:0032147activation of protein kinase activity
BPISSGO:0034115negative regulation of heterotypic cell-cell adhesion
BPISSGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPISSGO:0045415negative regulation of interleukin-8 biosynthetic process
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0050679positive regulation of epithelial cell proliferation
BPISSGO:0051247positive regulation of protein metabolic process
BPISSGO:0060761negative regulation of response to cytokine stimulus
BPIEAGO:0070375ERK5 cascade
BPISSGO:0071363cellular response to growth factor stimulus
BPTASGO:0071499cellular response to laminar fluid shear stress
BPISSGO:0090051negative regulation of cell migration involved in sprouting angiogenesis
BPISSGO:2000342negative regulation of chemokine (C-X-C motif) ligand 2 production
BPISSGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIEAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005819spindle
CCIEAGO:0005829cytosol
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004708MAP kinase kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: MAP2K5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K5


DatabasePathway IDPathway Des.
piderbb1_downstream_pathwayErbB1 downstream signaling
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
netpathPathway_EGFR1EGFR1
netpathPathway_TNFalphaTNFalpha
pharmgkbPA2032VEGF Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198765Signalling to ERK5
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartamapkpathwaymapkinase signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7512
iGMDRD219Bax channel blocker2
iGMDRD2PK-111952
iGMDRD61Kinetin riboside5
iGMDRD314Tanespimycin1
iGMDRD499PDMP2
iGMDRD132(-)-gallocatechin-3-O-gallate6
iGMDRD512nutlin 33
iGMDRD330BRD41324
iGMDRD84Lovastatin acid2
iGMDRD424Tamatinib5
iGMDRD779PRL-3 Inhibitor I2
iGMDRD150RITA2
iGMDRD562Navitoclax2
iGMDRD780PP-303
iGMDRD506Fedratinib2
iGMDRD577BIX012948
iGMDRD67PENFLURIDOL2
iGMDRD100Zebularine2
iGMDRD871BRD63683
iGMDRD286Nsc 6328392
iGMDRD414MST-3125
iGMDRD322FK 8662
iGMDRD23Gossypol2
iGMDRD138PX 122
iGMDRD121GMX17782
iGMDRD103SN-382
iGMDRD267Oligomycin A2
iGMDRD289Parthenolide5
iGMDRD221Tamoxifen3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K5

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