PIK3C2B


Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaMIM:602838Ensembl:ENSG00000133056HGNC:HGNC:8972PA333051q32.1

GO terms in PIK3C2B


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005783endoplasmic reticulum
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCIBAGO:0016020membrane
CCIEAGO:0030139endocytic vesicle
BPNDGO:0008150biological_process
BPIEAGO:0009267cellular response to starvation
BPIBAGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0016477cell migration
BPIBAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0043491protein kinase B signaling
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIBAGO:0048015phosphatidylinositol-mediated signaling
BPIEAGO:1905037autophagosome organization
MFIEAGO:0001727lipid kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:00163031-phosphatidylinositol-3-kinase activity
MFIBAGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFNASGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFIEAGO:0035091phosphatidylinositol binding
MFIBAGO:0052742phosphatidylinositol kinase activity

Gene expression in normal tissue: PIK3C2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3C2B


DatabasePathway IDPathway Des.
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP710DNA Damage Response (only ATM dependent)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD270Ciclosporin2
iGMDRD8024-methylfasudil3
iGMDRD318PAC-13
iGMDRD441TW 371
iGMDRD187BRD98762
iGMDRD887Compound 23 citrate3
iGMDRD399Selumetinib2
iGMDRD562Navitoclax2
iGMDRD780PP-303
iGMDRD268Cerulenin2
iGMDRD126Tipifarnib2
iGMDRD554CHEMBL14341372
iGMDRD579PF7502
iGMDRD427ABT7372
iGMDRD546BMS-7548074
iGMDRD483SCH-5290742
iGMDRD446LY 21832402
iGMDRD193Fqi11
iGMDRD394BX-7953
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B2
iGMDRD103SN-382
iGMDRD158NSC1415403
iGMDRD6AM-5802
iGMDRD221Tamoxifen1
iGMDRD434BMS-5369242
iGMDRD77Itraconazole3
iGMDRD414MST-3121
iGMDRD871BRD63683
iGMDRD286Nsc 6328392
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib4
iGMDRD512nutlin 35
iGMDRD116CD4371
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD405PIK-751
iGMDRD79Gemcitabine2
iGMDRD499PDMP2
iGMDRD219Bax channel blocker2
iGMDRD177Teniposide3
iGMDRD605AZD64821
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD883CIL55A5
iGMDRD154NSC237662

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3C2B

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