PIK3C2B
Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta | MIM:602838 | Ensembl:ENSG00000133056 | HGNC:HGNC:8972 | PA33305 | 1q32.1 |
GO terms in PIK3C2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0030139 | endocytic vesicle |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0009267 | cellular response to starvation |
| BP | IBA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:1905037 | autophagosome organization |
| MF | IEA | GO:0001727 | lipid kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IBA | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | NAS | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
Gene expression in normal tissue: PIK3C2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3C2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD883 | CIL55A | 5 |
| iGMDRD154 | NSC23766 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3C2B
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