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DST

Summary: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
dystonin	MIM:113810	Ensembl:ENSG00000151914	HGNC:HGNC:1090	PA25399	6p12.1

Gene Categories:

DRUGGABLE GENOME

GO terms in DST

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0003779	actin binding
MF	IPI	GO:0005178	integrin binding
MF	IBA	GO:0005198	structural molecule activity
MF	IEA	GO:0005509	calcium ion binding
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008017	microtubule binding
MF	IPI	GO:0008022	protein C-terminus binding
MF	IBA	GO:0045296	cadherin binding
MF	IDA	GO:0051010	microtubule plus-end binding
BP	IMP	GO:0007010	cytoskeleton organization
BP	IEA	GO:0007155	cell adhesion
BP	NAS	GO:0007229	integrin-mediated signaling pathway
BP	ISS	GO:0008090	retrograde axonal transport
BP	IDA	GO:0009611	response to wounding
BP	IMP	GO:0030011	maintenance of cell polarity
BP	IBA	GO:0031122	cytoplasmic microtubule organization
BP	IBA	GO:0031581	hemidesmosome assembly
BP	IBA	GO:0042060	wound healing
BP	IBA	GO:0045104	intermediate filament cytoskeleton organization
BP	IEP	GO:0045104	intermediate filament cytoskeleton organization
BP	ISS	GO:0045104	intermediate filament cytoskeleton organization
BP	NAS	GO:0045104	intermediate filament cytoskeleton organization
BP	IMP	GO:0048870	cell motility
CC	TAS	GO:0005604	basement membrane
CC	HDA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IEA	GO:0005635	nuclear envelope
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	ISS	GO:0005737	cytoplasm
CC	IEA	GO:0005789	endoplasmic reticulum membrane
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IBA	GO:0005882	intermediate filament
CC	IEA	GO:0005882	intermediate filament
CC	HDA	GO:0005925	focal adhesion
CC	IBA	GO:0005925	focal adhesion
CC	IEA	GO:0005938	cell cortex
CC	NAS	GO:0009925	basal plasma membrane
CC	IDA	GO:0015630	microtubule cytoskeleton
CC	IBA	GO:0016020	membrane
CC	IEA	GO:0016021	integral component of membrane
CC	IEA	GO:0030018	Z disc
CC	IBA	GO:0030056	hemidesmosome
CC	TAS	GO:0030056	hemidesmosome
CC	IDA	GO:0031252	cell leading edge
CC	IDA	GO:0031410	cytoplasmic vesicle
CC	IEA	GO:0031673	H zone
CC	IDA	GO:0035371	microtubule plus-end
CC	IEA	GO:1904115	axon cytoplasm

Gene expression in normal tissue: DST

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DST

Database	Pathway ID	Pathway Des.
netpath	Pathway_Alpha6Beta4Integrin	Alpha6Beta4Integrin
pid	tap63pathway	Validated transcriptional targets of TAp63 isoforms
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474290	Collagen formation
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures
reactome	R-HSA-446107	Type I hemidesmosome assembly
reactome	R-HSA-446728	Cell junction organization

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD107	Valdecoxib	2
iGMDRD2	PK-11195	2
iGMDRD639	YK 4-279	2
iGMDRD394	BX-795	2
iGMDRD466	Chaetocin	1
iGMDRD433	Lexibulin	4
iGMDRD151	CHM-1	5
iGMDRD126	Tipifarnib	4
iGMDRD420	Leucascandrolide A	4
iGMDRD670	ML 210	6
iGMDRD781	Sirolimus	4
iGMDRD483	SCH-529074	1
iGMDRD399	Selumetinib	1
iGMDRD74	Idarubicin	1
iGMDRD188	Piperlongumine	4
iGMDRD888	Compound 44	2
iGMDRD369	TGX-115	1
iGMDRD64	Parbendazole	6
iGMDRD356	PNU-74654	2
iGMDRD23	Gossypol	8
iGMDRD260	FQI-2	6
iGMDRD171	Pemetrexed	2
iGMDRD52	Rotenone	2
iGMDRD237	ABT-751	2
iGMDRD123	Isoevodiamine	4
iGMDRD248	BRD4354	3
iGMDRD532	Olaparib	1
iGMDRD150	RITA	4
iGMDRD286	Nsc 632839	4
iGMDRD366	PI-103	3
iGMDRD329	Merck60	6
iGMDRD147	Prima-1	2
iGMDRD552	AZD-1775	4
iGMDRD263	AACOCF3	2
iGMDRD137	Indisulam	3
iGMDRD251	ML162	2
iGMDRD202	Curcumin	4
iGMDRD158	NSC141540	4
iGMDRD103	SN-38	5
iGMDRD289	Parthenolide	5
iGMDRD705	Nakiterpiosin	3
iGMDRD221	Tamoxifen	4
iGMDRD77	Itraconazole	2
iGMDRD213	SMR000068650	4
iGMDRD201	SKI II	2
iGMDRD446	LY 2183240	3
iGMDRD193	Fqi1	6
iGMDRD163	all trans Retinoic Acid	2
iGMDRD280	CYTOCHALASIN B	2
iGMDRD634	SCHEMBL2608041	2
iGMDRD554	CHEMBL1434137	3
iGMDRD1008	SR-II-138A	2
iGMDRD579	PF750	3
iGMDRD772	BRD4770	2
iGMDRD144	NSC95397	2
iGMDRD100	Zebularine	2
iGMDRD398	Sepantronium	2
iGMDRD577	BIX01294	5
iGMDRD60	Quinoclamine	2
iGMDRD690	PRIMA-1MET	2
iGMDRD451	Serdemetan	2
iGMDRD268	Cerulenin	5
iGMDRD138	PX 12	6
iGMDRD255	SB225002	4
iGMDRD782	DC-45-A2	3
iGMDRD441	TW 37	6
iGMDRD885	Compound 110	2
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD211	(1S,3R)-RSL3	5
iGMDRD132	(-)-gallocatechin-3-O-gallate	1
iGMDRD307	Manumycin A	2
iGMDRD607	Ubistatin B	3
iGMDRD512	nutlin 3	4
iGMDRD345	Compound 10b [PMID: 11504634]	4
iGMDRD116	CD437	6
iGMDRD414	MST-312	3
iGMDRD269	Purmorphamine	2
iGMDRD246	NPC26	4
iGMDRD505	Pevonedistat	6
iGMDRD300	Tozasertib	2
iGMDRD82	Quiflapon	2
iGMDRD42	Vorinostat	1
iGMDRD434	BMS-536924	4
iGMDRD6	AM-580	2
iGMDRD267	Oligomycin A	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DST

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.