DST
Summary: This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namedystonin OMIM IDMIM:113810 Ensembl IDEnsembl:ENSG00000151914 HGNC IDHGNC:HGNC:1090 PHARMGKB IDPA25399 Map Location6p12.1 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in DST
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IBA | GO:0005198 | structural molecule activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008017 | microtubule binding |
Gene expression in normal tissue: DST
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DST
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474290 | Collagen formation |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-2022090 | Assembly of collagen fibrils and other multimeric structures |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DST
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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