RIMS2
Summary: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| regulating synaptic membrane exocytosis 2 | MIM:606630 | Ensembl:ENSG00000176406 | HGNC:HGNC:17283 | PA38445 | 8q22.3 |
GO terms in RIMS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
| MF | IEA | GO:0017137 | Rab GTPase binding |
| MF | IBA | GO:0044325 | ion channel binding |
| MF | ISS | GO:0044325 | ion channel binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006886 | intracellular protein transport |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0017156 | calcium ion regulated exocytosis |
| BP | ISS | GO:0017157 | regulation of exocytosis |
| BP | ISS | GO:0019933 | cAMP-mediated signaling |
| BP | ISS | GO:0030073 | insulin secretion |
| BP | IBA | GO:0042391 | regulation of membrane potential |
| BP | ISS | GO:0042391 | regulation of membrane potential |
| BP | IBA | GO:0048167 | regulation of synaptic plasticity |
| BP | IBA | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| BP | ISS | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter |
| BP | IBA | GO:0050806 | positive regulation of synaptic transmission |
| BP | ISS | GO:0061669 | spontaneous neurotransmitter secretion |
| BP | ISS | GO:0097151 | positive regulation of inhibitory postsynaptic potential |
| BP | IDA | GO:1903861 | positive regulation of dendrite extension |
| BP | IBA | GO:2000300 | regulation of synaptic vesicle exocytosis |
| BP | ISS | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| CC | IEA | GO:0005622 | intracellular |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0042734 | presynaptic membrane |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IBA | GO:0045202 | synapse |
| CC | TAS | GO:0048786 | presynaptic active zone |
| CC | IBA | GO:0048788 | cytoskeleton of presynaptic active zone |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IBA | GO:0098831 | presynaptic active zone cytoplasmic component |
Gene expression in normal tissue: RIMS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD226 | ML006 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD77 | Itraconazole | 4 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD522 | ML-030 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD85 | Ursolic acid | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIMS2
CLASSFICATION
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