RIMS2
Summary: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis. [provided by RefSeq, Feb 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606630 Ensembl IDEnsembl:ENSG00000176406 HGNC IDHGNC:HGNC:17283 PHARMGKB IDPA38445 Map Location8q22.3 | |||||
GO terms in RIMS2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
| MF | IEA | GO:0017137 | Rab GTPase binding |
| MF | IBA | GO:0044325 | ion channel binding |
| MF | ISS | GO:0044325 | ion channel binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RIMS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIMS2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIMS2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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