CARD14
Summary: This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607211 Ensembl IDEnsembl:ENSG00000141527 HGNC IDHGNC:HGNC:16446 PHARMGKB IDPA134959119 Map Location17q25.3 | |||||
GO terms in CARD14
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0050700 | CARD domain binding |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005886 | plasma membrane |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
Gene expression in normal tissue: CARD14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARD14
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARD14
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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