TLN1
Summary: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| talin 1 | MIM:186745 | Ensembl:ENSG00000137076 | HGNC:HGNC:11845 | PA36547 | 9p13.3 |
GO terms in TLN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001786 | phosphatidylserine binding |
| MF | IPI | GO:0005178 | integrin binding |
| MF | NAS | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0017166 | vinculin binding |
| MF | IPI | GO:0030274 | LIM domain binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051015 | actin filament binding |
| CC | ISS | GO:0001726 | ruffle |
| CC | TAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | ISS | GO:0005925 | focal adhesion |
| CC | NAS | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | NAS | GO:0007016 | cytoskeletal anchoring at plasma membrane |
| BP | TAS | GO:0007043 | cell-cell junction assembly |
| BP | IEA | GO:0007044 | cell-substrate junction assembly |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0030866 | cortical actin cytoskeleton organization |
| BP | IEA | GO:0033622 | integrin activation |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | HMP | GO:0070527 | platelet aggregation |
Gene expression in normal tissue: TLN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | rhopathway | rho cell motility signaling pathway |
| biocarta | ucalpainpathway | ucalpain and friends in cell spread |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD577 | BIX01294 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLN1
CLASSFICATION
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