TLN1


Summary: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
talin 1MIM:186745Ensembl:ENSG00000137076HGNC:HGNC:11845PA365479p13.3

GO terms in TLN1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001786phosphatidylserine binding
MFIPIGO:0005178integrin binding
MFNASGO:0005200structural constituent of cytoskeleton
MFIPIGO:0005515protein binding
MFIPIGO:0017166vinculin binding
MFIPIGO:0030274LIM domain binding
MFIEAGO:0035091phosphatidylinositol binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0051015actin filament binding
CCISSGO:0001726ruffle
CCTASGO:0005576extracellular region
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCHDAGO:0005925focal adhesion
CCISSGO:0005925focal adhesion
CCNASGO:0005925focal adhesion
CCIEAGO:0009986cell surface
CCIEAGO:0032587ruffle membrane
CCHDAGO:0070062extracellular exosome
BPTASGO:0002576platelet degranulation
BPTASGO:0006936muscle contraction
BPNASGO:0007016cytoskeletal anchoring at plasma membrane
BPTASGO:0007043cell-cell junction assembly
BPIEAGO:0007044cell-substrate junction assembly
BPIEAGO:0007229integrin-mediated signaling pathway
BPIEAGO:0016032viral process
BPIEAGO:0030866cortical actin cytoskeleton organization
BPIEAGO:0033622integrin activation
BPTASGO:0036498IRE1-mediated unfolded protein response
BPHMPGO:0070527platelet aggregation

Gene expression in normal tissue: TLN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TLN1


DatabasePathway IDPathway Des.
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaintegrinpathwayintegrin signaling pathway
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartarhopathwayrho cell motility signaling pathway
biocartaucalpainpathwayucalpain and friends in cell spread
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-354192Integrin alphaIIb beta3 signaling
reactomeR-HSA-354194GRB2:SOS provides linkage to MAPK signaling for Integrins
reactomeR-HSA-372708p130Cas linkage to MAPK signaling for integrins
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)
reactomeR-HSA-9006921Integrin signaling
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3472XBP1(S) activates chaperone genes
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events
pidnectin_pathwayNectin adhesion pathway
pidrhoa_pathwayRhoA signaling pathway
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide3
iGMDRD405PIK-754
iGMDRD126Tipifarnib5
iGMDRD210AC556491
iGMDRD599Salermide3
iGMDRD889Compound 7d-cis2
iGMDRD425ERASTIN1
iGMDRD297Austocystin D2
iGMDRD280CYTOCHALASIN B1
iGMDRD375GW-4058332
iGMDRD154NSC237661
iGMDRD945ML2143
iGMDRD85Ursolic acid1
iGMDRD499PDMP1
iGMDRD57Chloropentafluorobenzene1
iGMDRD698Neratinib3
iGMDRD351GW843682X1
iGMDRD237ABT-7513
iGMDRD221Tamoxifen3
iGMDRD105Triptolide2
iGMDRD6AM-5802
iGMDRD434BMS-5369242
iGMDRD192CIL563
iGMDRD267Oligomycin A2
iGMDRD294Batimastat3
iGMDRD513BML-2593
iGMDRD137Indisulam3
iGMDRD871BRD63681
iGMDRD414MST-3125
iGMDRD67PENFLURIDOL3
iGMDRD577BIX012943

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLN1

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