TLN1

Summary: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametalin 1
OMIM IDMIM:186745
Ensembl IDEnsembl:ENSG00000137076
HGNC IDHGNC:HGNC:11845
PHARMGKB IDPA36547
Map Location9p13.3

GO terms in TLN1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0001786 phosphatidylserine binding
MF IPI GO:0005178 integrin binding
MF NAS GO:0005200 structural constituent of cytoskeleton
MF IPI GO:0005515 protein binding
MF IPI GO:0017166 vinculin binding
MF IPI GO:0030274 LIM domain binding
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Gene expression in normal tissue: TLN1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 38undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11

Gene-drug pathway distribution

undefined27Leukocyte transendothelial migration1Drug metabolism - cytochrome P4501Cell cycle1Ferroptosis1

Pathways in TLN1


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Database
Pathway ID
Pathway Des.
biocarta ecmpathway erk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocarta integrinpathway integrin signaling pathway
biocarta mcalpainpathway mcalpain and friends in cell motility
biocarta rhopathway rho cell motility signaling pathway
biocarta ucalpainpathway ucalpain and friends in cell spread
reactome R-HSA-109582 Hemostasis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD494 Neopeltolide 3
iGMDRD405 PIK-75 4
iGMDRD126 Tipifarnib 5
iGMDRD210 AC55649 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TLN1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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