PTPRC
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine phosphatase, receptor type C | MIM:151460 | Ensembl:ENSG00000081237 | HGNC:HGNC:9666 | PA34011 | 1q31.3-q32.1 |
GO terms in PTPRC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| BP | ISS | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| BP | IMP | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0002378 | immunoglobulin biosynthetic process |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | ISS | GO:0006469 | negative regulation of protein kinase activity |
| BP | ISS | GO:0006470 | protein dephosphorylation |
| BP | IMP | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | ISS | GO:0016311 | dephosphorylation |
| BP | ISS | GO:0030217 | T cell differentiation |
| BP | IMP | GO:0030890 | positive regulation of B cell proliferation |
| BP | IEA | GO:0035335 | peptidyl-tyrosine dephosphorylation |
| BP | ISS | GO:0042100 | B cell proliferation |
| BP | ISS | GO:0042102 | positive regulation of T cell proliferation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0044770 | cell cycle phase transition |
| BP | NAS | GO:0045860 | positive regulation of protein kinase activity |
| BP | IMP | GO:0048539 | bone marrow development |
| BP | IMP | GO:0048864 | stem cell development |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | ISS | GO:0050853 | B cell receptor signaling pathway |
| BP | ISS | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway |
| BP | ISS | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | ISS | GO:0051607 | defense response to virus |
| BP | ISS | GO:0051726 | regulation of cell cycle |
| BP | IMP | GO:2000473 | positive regulation of hematopoietic stem cell migration |
| BP | IMP | GO:2000648 | positive regulation of stem cell proliferation |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IDA | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0004725 | protein tyrosine phosphatase activity |
| MF | TAS | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: PTPRC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_TCR | TCR |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa05340 | Primary immunodeficiency - Homo sapiens (human) |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202427 | Phosphorylation of CD3 and TCR zeta chains |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-416700 | Other semaphorin interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD772 | BRD4770 | 6 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 6 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 6 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD85 | Ursolic acid | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRC
CLASSFICATION
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