PTPRC
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:151460 Ensembl IDEnsembl:ENSG00000081237 HGNC IDHGNC:HGNC:9666 PHARMGKB IDPA34011 Map Location1q31.3-q32.1 | |||||
GO terms in PTPRC
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0001915 | negative regulation of T cell mediated cytotoxicity |
| BP | ISS | GO:0001960 | negative regulation of cytokine-mediated signaling pathway |
| BP | IMP | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0002378 | immunoglobulin biosynthetic process |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | ISS | GO:0006469 | negative regulation of protein kinase activity |
Gene expression in normal tissue: PTPRC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTPRC
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTPRC
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.