PRKCG
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C gamma | MIM:176980 | Ensembl:ENSG00000126583 | HGNC:HGNC:9402 | PA33766 | 19q13.42 |
GO terms in PRKCG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004698 | calcium-dependent protein kinase C activity |
| MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0097060 | synaptic membrane |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0007611 | learning or memory |
| BP | IEA | GO:0007635 | chemosensory behavior |
| BP | IDA | GO:0016310 | phosphorylation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | ISS | GO:0032095 | regulation of response to food |
| BP | IDA | GO:0032425 | positive regulation of mismatch repair |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0042177 | negative regulation of protein catabolic process |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043278 | response to morphine |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0048265 | response to pain |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | IEA | GO:0050764 | regulation of phagocytosis |
| BP | IEA | GO:0060384 | innervation |
| BP | ISS | GO:1901799 | negative regulation of proteasomal protein catabolic process |
| BP | IEA | GO:1990911 | response to psychosocial stress |
Gene expression in normal tissue: PRKCG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| pid | endothelinpathway | Endothelins |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| kegg | hsa05032 | Morphine addiction - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111933 | Calmodulin induced events |
| reactome | R-HSA-111996 | Ca-dependent events |
| reactome | R-HSA-111997 | CaM pathway |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-114516 | Disinhibition of SNARE formation |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-399719 | Trafficking of AMPA receptors |
| reactome | R-HSA-399721 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-5099900 | WNT5A-dependent internalization of FZD4 |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD116 | CD437 | 3 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD486 | Tosedostat | 4 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD698 | Neratinib | 4 |
| iGMDRD221 | Tamoxifen | 7 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD202 | Curcumin | 8 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD263 | AACOCF3 | 4 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD506 | Fedratinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCG
CLASSFICATION
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