PRKCG


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:176980
PHARMGKB IDPA33766
Map Location19q13.42

GO terms in PRKCG


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0004672 protein kinase activity
MF IBA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004697 protein kinase C activity
MF TAS GO:0004698 calcium-dependent protein kinase C activity
MF IDA GO:0004712 protein serine/threonine/tyrosine kinase activity
MF IEA GO:0005524 ATP binding
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Gene expression in normal tissue: PRKCG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCG


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Database
Pathway ID
Pathway Des.
wikipathways WP2012 miRs in Muscle Cell Differentiation
wikipathways WP2261 Signaling Pathways in Glioblastoma
wikipathways WP2636 Common Pathways Underlying Drug Addiction
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP306 Focal Adhesion
wikipathways WP35 G Protein Signaling Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD116 CD437 3
iGMDRD652 UNC0638 3
iGMDRD307 Manumycin A 2
iGMDRD486 Tosedostat 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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