PRKCG
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:176980 Ensembl IDEnsembl:ENSG00000126583 HGNC IDHGNC:HGNC:9402 PHARMGKB IDPA33766 Map Location19q13.42 |
GO terms in PRKCG
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0004672 | protein kinase activity |
MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
MF | TAS | GO:0004697 | protein kinase C activity |
MF | TAS | GO:0004698 | calcium-dependent protein kinase C activity |
MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: PRKCG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCG
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
wikipathways | WP2636 | Common Pathways Underlying Drug Addiction |
wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
wikipathways | WP306 | Focal Adhesion |
wikipathways | WP35 | G Protein Signaling Pathways |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |