FASN
Summary: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fatty acid synthase | MIM:600212 | Ensembl:ENSG00000169710 | HGNC:HGNC:3594 | PA28006 | 17q25.3 |
GO terms in FASN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | HDA | GO:0001649 | osteoblast differentiation |
| BP | IEA | GO:0006084 | acetyl-CoA metabolic process |
| BP | TAS | GO:0006631 | fatty acid metabolic process |
| BP | IEA | GO:0006633 | fatty acid biosynthetic process |
| BP | IEA | GO:0030879 | mammary gland development |
| BP | TAS | GO:0031325 | positive regulation of cellular metabolic process |
| BP | TAS | GO:0045540 | regulation of cholesterol biosynthetic process |
| BP | TAS | GO:0046949 | fatty-acyl-CoA biosynthetic process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0071353 | cellular response to interleukin-4 |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0042587 | glycogen granule |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004312 | fatty acid synthase activity |
| MF | IEA | GO:0004313 | [acyl-carrier-protein] S-acetyltransferase activity |
| MF | IEA | GO:0004314 | [acyl-carrier-protein] S-malonyltransferase activity |
| MF | IEA | GO:0004315 | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| MF | IEA | GO:0004316 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| MF | IEA | GO:0004320 | oleoyl-[acyl-carrier-protein] hydrolase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008144 | drug binding |
| MF | IEA | GO:0016295 | myristoyl-[acyl-carrier-protein] hydrolase activity |
| MF | IEA | GO:0016296 | palmitoyl-[acyl-carrier-protein] hydrolase activity |
| MF | IEA | GO:0031177 | phosphopantetheine binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0047117 | enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity |
| MF | IEA | GO:0047451 | 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| MF | IEA | GO:0070402 | NADPH binding |
| MF | IEA | GO:0102131 | 3-oxo-glutaryl-[acp] methyl ester reductase activity |
| MF | IEA | GO:0102132 | 3-oxo-pimeloyl-[acp] methyl ester reductase activity |
Gene expression in normal tissue: FASN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FASN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163765 | ChREBP activates metabolic gene expression |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-199220 | Vitamin B5 (pantothenate) metabolism |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-75105 | Fatty acyl-CoA biosynthesis |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| smpdb | SMP00456 | Fatty Acid Biosynthesis |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2011 | SREBF and miR33 in cholesterol and lipid homeostasis |
| wikipathways | WP2706 | Activation of gene expression by SREBF (SREBP) |
| wikipathways | WP2874 | Liver X Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP357 | Fatty Acid Biosynthesis |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3961 | fig-met-1-last-solution |
| wikipathways | WP3965 | Lipid Metabolism Pathway |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| humancyc | FASYN-ELONG-PWY | fatty acid elongation -- saturated |
| humancyc | PWY-5966-1 | fatty acid biosynthesis initiation |
| humancyc | PWY-5994 | palmitate biosynthesis |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | p73pathway | p73 transcription factor network |
| kegg | hsa00061 | Fatty acid biosynthesis - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD858 | BRD-K71935468 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD48 | Dexamethasone | 5 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD551 | Ponatinib | 2 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD159 | 3-Chloro-L-alanine | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD506 | Fedratinib | 8 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD441 | TW 37 | 6 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD138 | PX 12 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FASN
CLASSFICATION
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