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FASN

Summary: The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namefatty acid synthase OMIM IDMIM:600212 Ensembl IDEnsembl:ENSG00000169710 HGNC IDHGNC:HGNC:3594 PHARMGKB IDPA28006 Map Location17q25.3

Gene Categories:

DRUGGABLE GENOME SHORT CHAIN DEHYDROGENASE REDUCTASE

GO terms in FASN

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	HDA	GO:0001649	osteoblast differentiation
BP	IEA	GO:0006084	acetyl-CoA metabolic process
BP	TAS	GO:0006631	fatty acid metabolic process
BP	IEA	GO:0006633	fatty acid biosynthetic process
BP	IEA	GO:0030879	mammary gland development
BP	TAS	GO:0031325	positive regulation of cellular metabolic process

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Gene expression in normal tissue: FASN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FASN

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-163685	Integration of energy metabolism
reactome	R-HSA-163765	ChREBP activates metabolic gene expression
reactome	R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactome	R-HSA-196849	Metabolism of water-soluble vitamins and cofactors

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD945	ML214	3
iGMDRD405	PIK-75	2
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD424	Tamatinib	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FASN

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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