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iGMDRD48

Canonical SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C

InChI: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI Key: UREBDLICKHMUKA-CXSFZGCWSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Dexamethasone	CHEMBL384467	5743	D02592	DB01234	Alone	DAP000007	Small Molecule

Drug Class:

Adrenal Cortex Hormones Adrenals Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Alimentary Tract and Metabolism Anti-Acne Preparations Anti-Acne Preparations for Topical Use Anti-Inflammatory Agents Antiemetics Antineoplastic Agents Antineoplastic Agents, Hormonal Autonomic Agents BCRP/ABCG2 Inhibitors Cardiovascular System Central Nervous System Agents Corticosteroids Corticosteroids for Local Oral Treatment Corticosteroids for Systemic Use Corticosteroids for Systemic Use, Plain Corticosteroids, Dermatological Preparations Corticosteroids, Moderately Potent (Group II)Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (moderate)Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Dermatologicals Gastrointestinal Agents Glucocorticoids Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hyperglycemia-Associated Agents Immunosuppressive Agents Inducers of Drug Clearance Nasal Preparations Ophthalmological and Otological Preparations Ophthalmologicals Otologicals P-glycoprotein/ABCB1 Inducers P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Peripheral Nervous System Agents Polycyclic Compounds Pregnadienes Pregnadienetriols Pregnanes Respiratory System Sensory Organs Steroids Steroids, Fluorinated Stomatological Preparations Systemic Hormonal Preparations, Excl. Sex Hormones and Insulins Vasoprotectives

Drug Targets:

NR3C1 (P04150)NR0B1 (P51843)ANXA1 (P04083)NOS2 (P35228)NR1I2 (O75469)

Drug Pathways:

Neuroactive ligand-receptor interaction

Drug Synonyms:

Dexamethasone beloxil (USAN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7750	ZMYM2	2
2200	FBN1	1
9706	ULK2	3
5295	PIK3R1	1
8289	ARID1A	2
3939	LDHA	2
79820	CATSPERB	2
3841	KPNA5	2
140469	MYO3B	3
5596	MAPK4	3
26576	SRPK3	3
55351	STK32B	1
5314	PKHD1	2
9578	CDC42BPB	2
83983	TSSK6	2
1973	EIF4A1	6
157285	PRAG1	3
84433	CARD11	3
7533	YWHAH	2
23152	CIC	1
7184	HSP90B1	2
139728	PNCK	5
7157	TP53	2
863	CBFA2T3	3
7422	VEGFA	3
6535	SLC6A8	1
3718	JAK3	3
7204	TRIO	3
5727	PTCH1	3
4293	MAP3K9	2
5366	PMAIP1	3
4609	MYC	3
10461	MERTK	3
1031	CDKN2C	3
894	CCND2	2
8900	CCNA1	3
23532	PRAME	2
120892	LRRK2	2
4298	MLLT1	3
53904	MYO3A	1
440	ASNS	1
2194	FASN	5
6778	STAT6	3
4067	LYN	3
3552	IL1A	2
3815	KIT	4
4666	NACA	3
4205	MEF2A	2
2261	FGFR3	2
2044	EPHA5	2
5624	PROC	2

Gene in drug-gene network: Network Plot

Models in Dexamethasone

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.