PIK3R1


Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in PIK3R1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP ISS GO:0001678 cellular glucose homeostasis
BP IEA GO:0001953 negative regulation of cell-matrix adhesion
BP IEA GO:0006468 protein phosphorylation
BP IEA GO:0006606 protein import into nucleus
BP TAS GO:0007173 epidermal growth factor receptor signaling pathway
BP TAS GO:0007186 G-protein coupled receptor signaling pathway
Showing 1 to 6 of 81 rows rows per page

Gene expression in normal tissue: PIK3R1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3R1


Loading, please wait...
Database
Pathway ID
Pathway Des.
pid a6b1_a6b4_integrin_pathway a6b1 and a6b4 Integrin signaling
pid angiopoietinreceptor_pathway Angiopoietin receptor Tie2-mediated signaling
pid ar_nongenomic_pathway Nongenotropic Androgen signaling
pid avb3_integrin_pathway Integrins in angiogenesis
pid avb3_opn_pathway Osteopontin-mediated events
pid bcr_5pathway BCR signaling pathway
Showing 1 to 6 of 394 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 3
iGMDRD394 BX-795 4
iGMDRD297 Austocystin D 1
iGMDRD470 Trametinib 1
Showing 1 to 4 of 58 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3R1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​