PIK3R1
Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:171833 Ensembl IDEnsembl:ENSG00000145675 HGNC IDHGNC:HGNC:8979 PHARMGKB IDPA33312 Map Location5q13.1 |
GO terms in PIK3R1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | ISS | GO:0001678 | cellular glucose homeostasis |
BP | IEA | GO:0001953 | negative regulation of cell-matrix adhesion |
BP | IEA | GO:0006468 | protein phosphorylation |
BP | IEA | GO:0006606 | protein import into nucleus |
BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
Gene expression in normal tissue: PIK3R1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3R1
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Database | Pathway ID | Pathway Des. |
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pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
pid | avb3_integrin_pathway | Integrins in angiogenesis |
pid | avb3_opn_pathway | Osteopontin-mediated events |
pid | bcr_5pathway | BCR signaling pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3R1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |