iGMDRD694

Canonical SMILES: CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)C=CC4=CN=C5C(=C4OC)C=CN5)C(F)(F)F

InChI: InChI=1S/C32H34F3N5O2/c1-4-39-13-15-40(16-14-39)20-25-9-10-26(18-28(25)32(33,34)35)38-31(41)23-6-5-21(2)22(17-23)7-8-24-19-37-30-27(11-12-36-30)29(24)42-3/h5-12,17-19H,4,13-16,20H2,1-3H3,(H,36,37)(H,38,41)/b8-7+

InChI Key: UMBFDGUGXMOMHX-BQYQJAHWSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameHG6-64-1
Pubchem CID53302400
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

BRAF V600ETAKMAP4K5

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

6reactome: Immune System5reactome: Signaling by Receptor Tyrosine Kinases5reactome: Signal Transduction4reactome: Innate Immune System4reactome: Fc epsilon receptor (FCERI) signaling4reactome: Signaling by NTRKs3kegg: PI3K-Akt signaling pathway - Homo sapiens (human)3reactome: Cytokine Signaling in Immune system3kegg: Ras signaling pathway - Homo sapiens (human)3reactome: Signaling by ERBB2

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
5295 PIK3R1 1
7307 U2AF1 1
2322 FLT3 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in HG6-64-1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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